Long-term dysfunction of the proximal renal tubules leads to impaired tubular reabsorption
of amino acids, glucose, bicarbonate, and phosphate [7-9,11,12].
Caption: FIGURE 2: Renal tubular reabsorption
of free amino acids (TRR%) compared between group Tob- (o = CF patients that never received intravenous tobramycin) and group Tob+ (* = CF patients that received various courses of intravenous tobramycin).
Conclusions: It was thought that it was not appropriate to use tubular reabsorption
of phosphorus alone in the diagnosis of osteopenia of prematurity.
Reduced Tubular Reabsorption
Is a Major Determinant of Increased Urinary CTGF in Diabetic Mice.
The proposed mechanism of exercise-induced proteinuria involves increased glomerular permeability and exceeding the maximum tubular reabsorption
: Water solubility determines the extent to which reabsorption from the tubules occurs.
However, the homeostasis of carnitine is kept through very efficient mechanisms such as the ability ofthe human body to synthesize sufficient amounts of carnitine even under adverse dietetic management and a very efficient tubular reabsorption
of carnitine under normal conditions.
On the other hand, these results obviously indicate an elevation of renal tubular reabsorption
of ions in rbST-treated cows.
Among other factors, aldosterone, the salt retaining hormone, which is known for influencing water metabolism by altering renal tubular reabsorption
of sodium, is also known to be inactivated by the liver.
Our data, together with the literature findings, imply that while most secretory functions of the nephron are within normal limits during heavy muscle activity, some functions depending on glomerular permeability and tubular reabsorption
seem to be vulnerable (Table 1).
Cystatin C (CC), a small molecule (MW:13, 000), is filtered by the glomeruli and is followed by tubular reabsorption
and degradation resulting in excretion of a minute amount in the urine.
We have shown that stevioside induces hypotension, diuresis, natriuresis and kaliuresis (Melis et al., 1986) and a fall in renal tubular reabsorption
of glucose in rats (Melis, 1992).