tubular proteinuria


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Related to tubular proteinuria: glomerular proteinuria

proteinuria

 [pro″te-nu´re-ah]
an excess of serum proteins in the urine, such as in renal disease, after strenuous exercise, or in dehydration.
accidental proteinuria (adventitious proteinuria) proteinuria due not to a kidney disease but to some other condition such as hemorrhage in the urinary tract; called also false proteinuria.
athletic proteinuria effort proteinuria.
dietetic proteinuria (digestive proteinuria) functional proteinuria produced by the eating of certain foods.
effort proteinuria functional proteinuria occurring as a result of vigorous and prolonged exercise of the lower limbs; called also athletic proteinuria.
false proteinuria adventitious proteinuria.
functional proteinuria any proteinuria that is not due to renal disease, such as the transient proteinuria of pregnancy, effort proteinuria, and orthostatic proteinuria.
glomerular proteinuria the most common kind of proteinuria, being due to glomerular disease and abnormal permeability of the glomerular capillaries to protein.
orthostatic proteinuria a form of functional proteinuria, usually seen between the ages of ten and twenty, that occurs on standing erect and disappears on lying down.
overflow proteinuria that due to hemoglobin, myoglobin, or immunoglobulin loss into the urine due to excessive amounts in the bloodstream, such as in multiple myeloma; it is not usually associated with glomerular or tubular disease.
tubular proteinuria proteinuria due to excretion of proteins of low molecular weight such as immunoglobulins, which normally should be reabsorbed.

tubular proteinuria

The loss of relatively small amino acids, immunoglobulin light chains, and other small proteins (less than 25 kD) in the urine, because of failure of the renal tubules to reabsorb proteins that have been filtered by the glomerulus.
See also: proteinuria
References in periodicals archive ?
Long term follow up of proteinuria and estimated glomerular filtration rate in HIV patients with tubular proteinuria. PLoS One 2015 Nov;10(11):e0142491.
In critically ill patients with AKI increased urinary tubular proteinuria can identify patients who required aRRT.12 In our study we found that those who needed a longer duration of interim dialysis support have heavier tubular proteinuria.
Tubular proteinuria is a well-established adverse effect associated with Cd exposure at U-Cd > 4 [micro]g/g cr and/or B-Cd > 4 [micro]g/L in occupationally as well as environmentally exposed populations.
Based on these results, maybe continuous resistance trainings might cause increment of tubular proteinuria, although further investigation should be needed to could declare with complete confidence.
Dose-reponse relations between urinary cadmium and tubular proteinuria in adult workers.
Studies carried out among industrial workers in the 1980s have derived a threshold of urinary Cd of 10 [micro]g/g creatinine for the development of tubular proteinuria with an increased urinary excretion of [[beta].sub.2]-microglobulin or retinol-binding protein (2,4,10,11).
Both [[beta].sub.2]-microglobulin and [[alpha].sub.1]-microglobulin serve as organ-specific, early-effect biomarkers of tubular proteinuria and thus play a role in identifying early signs of cadmium-induced renal damage in those with potential exposures.
We used urinary protein [[alpha].sub.1]-microglobulin as a marker for tubular proteinuria and measured forearm bone mineral density using dual-energy X-ray absorptiometry.
Tubular proteinuria is characterized by the dominant excretion of low-molecular-weight proteins such as [[alpha].sub.1]-microglobulin (A1M) or retinol-binding protein (RBP), which correlate better with the extent of tubulo-interstitial damage than does determination of total 24-h protein concentrations (1).
The second, tubular proteinuria (an increase in the presence of low-molecular-weight proteins in the urine), is an indication of kidney dysfunction.
The second electrophoresis demonstrated a glomerular and tubular proteinuria with a suspicious broad [gamma]-region band (Fig.
A cross-sectional study in Sweden found that people with 1.0 [micro]g urinary cadmium/g creatinine had a 3-fold increase in risk of having tubular proteinuria, as measured by [[alpha].sub.1]-microglobulin (21).