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Etymology: L, tubulus, little tube; Gk, nekros, dead, osis, condition
the death of cells in the small tubules of the kidneys as a result of disease or injury.
Acute Tubular NecrosisA condition characterised by acute renal failure with oliguria, which returns to normal in days to weeks, with the caveat that 50% of patients die.
Aetiology Ischaemia—medical, obstetric, surgical, including transplantation (cold ischaemia); toxicity—drugs (aminoglycosides, amphotericin B, cyclosporine), chemicals (radiocontrast), pigments (myoglobin—crush syndrome, haemoglobinuria), sepsis, shock. Predisposing conditions Diabetes, liver disease, immunosuppression by toxic agents.
Management It is managed in transplanted kidneys in an expectant fashion as renal function may resume spontaneously in 2 to 4 weeks.
tubular necrosisSee Acute tubular necrosis.
1. pertaining to renal tubules.
2. pertaining to fallopian tube.
leakage of tubular fluid into the interstitium of the kidney is one of the factors in the pathogenesis of acute renal failure.
the concentrations of solutes at which the renal tubules are working at full capacity and further increases in concentration will not increase the function. Called also Tm.
acute necrosis of the tubular epithelium caused usually by ischemia or exposure to a nephrotoxin; in most cases the patient succumbs to uremia in a few days. See also nephrosis.
failure of the tubules to resorb small molecule proteins excreted by the glomerulus.
reabsorption of solutes from the glomerular filtrate by the tubules, the conservation of protein, glucose and bicarbonate, and the conservation of the water that accompanies them.
refers to all processes which occur with renal tubular fluid during its transport from glomerular space to renal pelvis.
tubular transport maximum
when the tubular transport maximum for a renal tubular solute is exceeded the solute appears in the urine.