High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma
and invasive lobular carcinoma.
An immunohistochemical comparison with tubular carcinoma
1) This would also explain why columnar cell hyperplasia without atypia has been reported to be common within or at the periphery of tubular carcinoma and/or LIN.
One should be aware of the possibility of small areas of tubular carcinoma (or well-differentiated infiltrating ductal carcinoma) in the setting of such flat lesion.
Low-grade flat DIN can commonly be found within and/or at the periphery of tubular carcinoma and displays very similar cytologic, immunohistochemical, and molecular-genetical abnormalities as those identified in more advanced low-grade DIN (DCIS) and tubular (or well-differentiated ductal) carcinoma.
Approximately one-third of intraductal tubular carcinomas
have an associated, typically grossly invisible, invasive adenocarcinoma.
Two were small acinar proliferations, 1 suspicious for tubular carcinoma and 1 for radial scar; both were confirmed on resection.
The radial scar was initially present on the second slide, while the tubular carcinoma was first detected on the fourth slide.
17,18) Yano et al studied a group of 6 papillary and 193 tubular carcinomas
of the stomach and showed that all papillary carcinomas (100%) were positive for HER2 overexpression compared to only 20.