Furthermore, the combination of p53, Ki-67, and [beta]-catenin could be a practical immunohistochemical panel to help distinguish DALM lesions from sporadic tubular adenomas
. In a study by Walsh et al, (136) almost 30% of adenoma-like DALMs expressed p53, whereas nuclear [beta]-catenin was more frequently expressed in sporadic adenomas (40%).
A computer search was done for pathology diagnoses of hyperplastic polyps, tubular adenomas
, tubulovillous adenomas, villous adenomas and colon adenocarcinoma using VISTA computerized medical record.
(1,2,3) Tubular adenomas
are characterised by uniform closely approximated tubular structures lined by epithelial and myoepithelial cells with little or no cytoplasmic vacuolisation.
Sporadic Nonampullary tubular adenomas
(SNADAs) of the duodenum are infrequently encountered during routine upper endoscopic examination (1-3).
C, Intraductal tubular adenoma
of pancreas showing predominantly tubular configuration with pyloric gland feature and low-grade atypia.
Other rare benign tumours encountered were fibroepithelial polyp, Papiloma with stromal sclerosis and tubular adenoma
Proximal ND-SP patients also showed an increased likelihood of having three or more synchronous small tubular adenomas
(less than 10 mm) on baseline colonoscopy, "which would have implications for surveillance," wrote the authors.
The prevalence of advanced proximal lesions was 4.0% (RR=2.6; 95% confidence interval [CI], 1.1-5.9) in the group with distal hyperplastic polyps (10.1% of the population), 7.1% (RR=4.0; 95% CI, 1.9-8.3) in the group with distal tubular adenoma
(a) Includes sessile serrated adenoma, villous adenoma, tubulovillous adenoma, and tubular adenoma
. Table 2.
Polyp characteristics for the tubular adenoma
group were similar--mean size was also 1 cm, mean number was 4.4, 79.8% were sessile, and, as in the HGD group, 100% were completely resected.
The neoplastic polyps include the adenomatous polyp, which may be identified histologically as a tubular adenoma
, tubulovillous adenoma, or villous adenoma.[1,7]
This patient also had five other lesions in the same area; one was a tubular adenoma
without atypia and four were villous adenomas without atypia.