Diaphragm contractions induced by phrenic nerve stimulation were fully inhibited by tubocurarine in a concentration-dependent manner ([IC.sub.50]=0.35 [+ or -] 0.05 [micro]M, n=4), thus showing their dependence on nicotinic receptor activation (Fig.
Given that serpentine exhibited a potent acetylcholinesterase inhibitory activity in the in vitro assay with the isolated enzyme, we tested whether serpentine would reverse tubocurarine blockade of diaphragm contractions as occurs for physostigmine (Fig.
A comparison of tubocurarine
, Rocuronium and cisatracuronium in the prevention and reduction of succinylcholine induced muscle fasciculations.
To name only a few of the important drugs in use today, aspirin, atropine, ephedrine, digoxin, morphine, quinine, reserpine and tubocurarine
serve as examples (Gilani, A.H.
Of the various pharmaceuticals used in modern medicine, aspirin, atropine, ephedrine, digoxin, morphine, quinine, reserpine and tubocurarine
serve as examples of drugs discovered through observations of indigenous medical practices (Gilani, A.H.
The effects of tubocurarine
elicited train of four muscle response and repiratory measurements in humans, Br J Anaesth 1975; 47: 570-573.
Comparison of tubocurarine
and pancuronium in nitrous oxide and oxygen.
Important modern drugs that have been derived from observations of traditional curing methods of indigenous people include aspirin, atropine, ephedrine, digoxin, morphine, quinine, reserpine and tubocurarine
was the drug of choice for operations of any significant duration, but because tubocurarine
lasted around thirty minutes, gallamine was often preferred for shorter operations.
Modern drugs like aspirin, atropine, ephedrine, digoxin, morphine, quinine, reserpine and tubocurarine
serve as examples, which were originally discovered through observations of traditional cure methods of indigenous peoples (Gilani, A.H., and A.U.
Even in recent times, plants have been an important source of modern drugs like aspirin, ephedrine, digoxin, quinine and tubocurarine
, to name only a few (Gilani, 2005).