tuberculin

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tuberculin

 [too-ber´ku-lin]
a sterile liquid containing the growth products of, or specific substances extracted from, the tubercle bacillus; used in various forms in the diagnosis of tuberculosis (see tuberculin test).
Old tuberculin a sterile solution of a heat-concentrated filtrate of tubercle bacillus culture grown on a special medium, used for tuberculin tests.
PPD tuberculin (purified protein derivative tuberculin) a sterile solution of a purified protein fraction precipitated from a filtrate of tubercle bacillus culture grown on a special medium, used for tuberculin tests.
tuberculin test any of a large number of skin tests for tuberculosis using a variety of different types of tuberculin and methods of application. The most reliable procedure, now standard, is intradermal injection (the mantoux test) of PPD (purified protein derivative); a positive result consists of a palpable and visible area of erythema and induration greater than 10 mm in diameter developing around the site of injection 48 to 72 hours after the injection. Intermediate strength tuberculin (5 TU) is generally used to test adults; a positive result is virtually diagnostic of a previous or current infection with Mycobacterium tuberculosis. Persons with a negative test are retested with second strength tuberculin (250 TU); in this test a positive reaction is frequently due to atypical mycobacteria infection and is thus nonspecific; a negative result indicates either absence of tuberculosis or the presence of cutaneous anergy due to overwhelming tuberculosis infection or to an associated immunocompromised condition such as HIV infection, Hodgkin's disease, or sarcoidosis.

tu·ber·cu·lin

(tū-ber'kyū-lin),
1. A glycerin-broth culture of Mycobacterium tuberculosis evaporated to 1/10 volume at 100°C and filtered; introduced by Robert Koch for the treatment of tuberculosis but now used chiefly for diagnostic tests; originally known as Koch old tuberculin (OT) or Koch original tuberculin
2. One or another of a relatively large number of extracts of Mycobacterium tuberculosis cultures, different from OT and now obsolete.

tuberculin

(to͝o-bûr′kyə-lĭn, tyo͝o-)
n.
A sterile liquid containing proteins extracted from cultures of tubercle bacilli and used in tests for tuberculosis.

tu·ber·cu·lin

(tū-bĕrkyū-lin)
A glycerin-broth culture of Mycobacterium tuberculosis evaporated to 1/10 volume at 100°C and filtered; introduced by Robert Koch for the treatment of tuberculosis but now used chiefly for diagnostic tests; originally known as Koch old tuberculin (OT) or Koch original tuberculin.

Tuberculin

A mixture of antigens obtained from the cultured bacteria that cause tuberculosis, Mycobacterium tuberculosis.
Mentioned in: Tuberculin Skin Test

tu·ber·cu·lin

(tū-bĕrkyū-lin)
A glycerin-broth culture of Mycobacterium tuberculosis evaporated to 110 volume at 100°C and filtered.
References in periodicals archive ?
All this immunosuppressive mechanism may result in depression of tuberculin induced blastogenesis, and decreased production of IL-2, generation of IL-2 receptor, and hence a negative tuberculin test in some patients with active tuberculosis with HIV negative sero status.Sometimes false negative tuberculin reaction can occur in both pulmonary tuberculosis patients with HIV seropositivity and HIV seronegativity.
In the present study, 59% HIV positive serostatus showed positive tuberculin reaction. This correlates with the study done by K.C.
suggest that HIV infection can depress tuberculin reactions before signs and symptoms develop.
The Advisory Committee for Elimination of Tuberculosis and the American Thoracic Society recommend that tuberculin reactions [greater than or equal to] 5 mm be considered positive in HIV-seropositive persons (regardless of BCG vaccination status) and that such persons be considered for isoniazid prophylaxis [2].
They believe that using the AM allergen in the set of diagnostic studies when differentiating tuberculin reactions in animals at arbitrarily satisfactory farmsteads allows understanding, to a certain extent, the epizootic situation in terms of TB among cattle (Michel, 2008).
At the same time, the differentiation between nonspecific tuberculin reactions and specific ones is understudied.Additional optimization approaches to improve test performance were examined and showed that the application of "a priori exclusions" of test results on the basis of reactivity to fortuitum PPD (sensitin produced from Mycobacterium fortuitum) and to a lesser degree, avian PPD, increased specificity without losing sensitivity (Michel et al., 2011).
However, efforts in CFs were more successful than DTCs in ensuring that persons with tuberculin reactions were evaluated.
The extensive use of BCG vaccination complicated the interpretation of tuberculin skin tests among school classmates of patient 2, since tuberculin reactions due to BCG vaccination cannot be reliably distinguished from those caused by M.