tuberculin reaction

Also found in: Dictionary, Thesaurus, Encyclopedia.

tuberculin reaction

hardening or blistering as a delayed reaction at the site of a tuberculin test, a positive result that indicates previous exposure to either the vaccine or the disease.


a sterile liquid containing the growth products of, or specific substances extracted from the tubercule bacillus; used in various forms in the diagnosis of tuberculosis.

heat concentrated synthetic medium (HCSM) tuberculin
similar to old tuberculin, but grown on synthetic medium.
new tuberculin
a suspension of the fragments of tubercle bacilli, freed from all soluble materials and with glycerine added.
old tuberculin
a sterile solution of concentrated, soluble products of the growth of the tubercle bacillus, adjusted to standard potency by addition of glycerin and isotonic sodium chloride solution, final glycerin content being about 50%.
purified protein derivative (PPD) of tuberculin
a form of tuberculin used in the testing of animals for tuberculosis; abbreviated PPD. It is a soluble protein fraction prepared from a synthetic medium on which the Mycobacterium bovis has been cultured. It has the advantage of reducing the number and severity of the reactions caused by nonspecific sensitizing materials in the culture medium in old tuberculin.
tuberculin reaction
the prototype delayed or type IV hypersensitivity; typified by swelling and redness at the site of inoculation of tuberculin.
tuberculin tests
a number of tests for tuberculosis, based on the use of tuberculin as a test agent, are used in animals. A short thermal test using a large volume of tuberculin injected subcutaneously is used in special circumstances. Most of the tests use an intradermal injection and a local swelling as a positive reaction.
References in periodicals archive ?
IMMUNOLOGICAL ANTI-INFLAMMATORY ACTIVITY: Tuberculin sensitivity test: Marked tuberculin reaction developed 24 hour after intradermal injection of PPD in the control group.
Among category A patients 9% showed no tuberculin reaction (anergy), 32% showed induration size between 1-5 mm, 27% showed induration size between 6-9 mm, 32% showed induration size of 10 or more than 10 mm.
suggest that HIV infection can depress tuberculin reactions before signs and symptoms develop.
They believe that using the AM allergen in the set of diagnostic studies when differentiating tuberculin reactions in animals at arbitrarily satisfactory farmsteads allows understanding, to a certain extent, the epizootic situation in terms of TB among cattle (Michel, 2008).
In a cross sectional study carried out in hospital employees in Spain, it was found that significant tuberculin reactions were more frequent among BCG-vaccinated (60%) than among non-vaccinated (29%) employees10.
Further observations on tuberculin reactions in active tuberculosis.
Staff at the DTCs and CFs typically 1) performed Mantoux tuberculin skin tests, 2) performed or arranged for HIV counseling and testing, 3) either referred persons with positive tuberculin reactions for evaluation (DTCs) or performed evaluations on site (CFs), 4) provided directly observed isoniazid (INH) preventive therapy to infected inmates and clients, and 5) monitored inmates and clients for toxicity to INH.
Tuberculin reactions in apparently healthy HIV-seropositive and HIV-seronegative women -- UGANDA.