tuberculin


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tuberculin

 [too-ber´ku-lin]
a sterile liquid containing the growth products of, or specific substances extracted from, the tubercle bacillus; used in various forms in the diagnosis of tuberculosis (see tuberculin test).
Old tuberculin a sterile solution of a heat-concentrated filtrate of tubercle bacillus culture grown on a special medium, used for tuberculin tests.
PPD tuberculin (purified protein derivative tuberculin) a sterile solution of a purified protein fraction precipitated from a filtrate of tubercle bacillus culture grown on a special medium, used for tuberculin tests.
tuberculin test any of a large number of skin tests for tuberculosis using a variety of different types of tuberculin and methods of application. The most reliable procedure, now standard, is intradermal injection (the mantoux test) of PPD (purified protein derivative); a positive result consists of a palpable and visible area of erythema and induration greater than 10 mm in diameter developing around the site of injection 48 to 72 hours after the injection. Intermediate strength tuberculin (5 TU) is generally used to test adults; a positive result is virtually diagnostic of a previous or current infection with Mycobacterium tuberculosis. Persons with a negative test are retested with second strength tuberculin (250 TU); in this test a positive reaction is frequently due to atypical mycobacteria infection and is thus nonspecific; a negative result indicates either absence of tuberculosis or the presence of cutaneous anergy due to overwhelming tuberculosis infection or to an associated immunocompromised condition such as HIV infection, Hodgkin's disease, or sarcoidosis.

tu·ber·cu·lin

(tū-ber'kyū-lin),
1. A glycerin-broth culture of Mycobacterium tuberculosis evaporated to 1/10 volume at 100°C and filtered; introduced by Robert Koch for the treatment of tuberculosis but now used chiefly for diagnostic tests; originally known as Koch old tuberculin (OT) or Koch original tuberculin
2. One or another of a relatively large number of extracts of Mycobacterium tuberculosis cultures, different from OT and now obsolete.

tuberculin

(to͝o-bûr′kyə-lĭn, tyo͝o-)
n.
A sterile liquid containing proteins extracted from cultures of tubercle bacilli and used in tests for tuberculosis.

tu·ber·cu·lin

(tū-bĕrkyū-lin)
A glycerin-broth culture of Mycobacterium tuberculosis evaporated to 1/10 volume at 100°C and filtered; introduced by Robert Koch for the treatment of tuberculosis but now used chiefly for diagnostic tests; originally known as Koch old tuberculin (OT) or Koch original tuberculin.

Tuberculin

A mixture of antigens obtained from the cultured bacteria that cause tuberculosis, Mycobacterium tuberculosis.
Mentioned in: Tuberculin Skin Test

tu·ber·cu·lin

(tū-bĕrkyū-lin)
A glycerin-broth culture of Mycobacterium tuberculosis evaporated to 110 volume at 100°C and filtered.
References in periodicals archive ?
Nationwide shortage of tuberculin skin test antigens: CDC recommendations for patient care and public health practice.
Tuberculin and quantiFERON.TB.gold tests for latent tuberculosis: A meta-analysis.
We found high rates of tuberculin conversion (11.8 conversions per 100 child-years) and all diagnosed TB disease (2.9 paediatric cases per 100 child-years).
Therefore, the present study was planned with the objectives to investigate the epidemiology of Paratuberculosis in cattle and buffaloes at selected areas and to compare the suitability of different diagnostic tests, including tuberculin testing, ELISA and ZN staining in the diagnosis of Paratuberculosis.
The difference in terms of positive results between the two commercially available tuberculin skin tests used (PPD tuberculin mammalian and Tubertest) was not statistically significant (p < 0.05).
Both avian and bovine Purified protein derivative (PPD) supplied by Prionics and the Tuberculin PPDs of Prionics Lelystad are already applied in over 50 million skin tests annually in Europe.
Conclusion: Latent tuberculosis infection prevalence was higher based on tuberculin skin test than QuantiFERON- Tuberculosis Gold In-Tube test.
Comparison of two interferon-gamma assays and tuberculin skin test for tracing tuberculosis contacts.
DISCUSSION: The diagnosis of tuberculosis in children rests largely on the result of relevant history, clinical examination, tuberculin test, radiological examination and history of contact.
Geographical latitude was investigated because BCG immunisation is known to have a lower impact on the immune response to tuberculin in areas closer to the equator.
Various studies have reported that high smear positivity and cavitatory lesions can more likely transmit infections and thus causing tuberculin skin testing positive in contacts and prevalence of active TB in these suspects is between 1.2% to 1.5%9.
The overall frequency of tuberculin skin testing positivity was 41.2% (56 out of the 136 subjects) using the cutt-off value of 10 mm.