(2013) Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen
Hirota et al., "Involvement of autophagy in trypsinogen
activation within the pancreatic acinar cells," Journal of Cell Biology, vol.
Early prediction of severity in acute pancreatitis by urinary trypsinogen
activation peptide: A multicentre study.
Publication Article title: 'NFATc3 Regulates Trypsinogen
Activation, Neutrophil Recruitment, and Tissue Damage in Acute Pancreatitis in Mice' Published in: Gastroenterology
It is, however, possible to identify most CF infants during the first days of life by measurement of blood immunoreactive trypsinogen
(IRT) (pancreatic pro-enzyme precursor of trypsin) and identification of CFTR mutations.
It is produced as trypsinogen
, and becomes acted on by another ferment--enterokinase, secreted by the small intestine.
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen
In the duodenum the intestinal enzyme enterokinase secreted by the mucosal cells cleaves off a small six amino acid terminal from trypsinogen
, converting the precursor into the active enzyme.
coli 116,000 Phosphorylase b from rabbit muslce 97,000 Albumin, bovine serum 66,000 Glutamic dehydrogenase from bovine liver 55,000 Ovalbumin from chicken egg 45,000 Glyceraldhyde-3-phosphate- dehydrogenises 36,000 Low range makers Molecular weights (Daltons) Carbonic anhydrase from bovine erythrocytes 29,000 Trypsinogen
from bovine erythrocytes 24,000 Trypsin inhibitor from soyabean 20,000 [alpha]-Lactalbumin from bovine milk 14,200 Aprotinin from bovine lung 6,5000 Table 2: Molecular weights of the L.
Increased levels of the trypsinogen
activation peptide, trypsinogen
2 (urine and serum), or anionic trypsinogen
2 can be detected early in the course of pancreatitis (35,36).
in the intestinal homogenate was first converted into trypsin by Enterokinase.
Induction of pancreatic trypsin by dietary amino acids in rats; four trypsinogen
isozymes and cholecystokinin messenger RNA.