Hypothalamic hamartomas are found in 33% of patients with true precocious puberty.
How many cases of true precocious puberty in girls are idiopathic?
Changes in the predicted adult height after gonadotropin-releasing hormone agonist treatment in girls with idiopathic true precocious puberty
It is appropriate for you to distinguish true precocious puberty
from precocious puberty secondary to a general underlying medical condition if this is within your comfort zone.
Of the 105 with true precocious puberty
, 26 (12%) were found to have potentially serious endocrine disorders such as adrenal gland problems, growth hormone deficiency, hypothyroidism (low thyroid function), and hyperthyroidism (overactive thyroid function).
However, the recommendations were made on the basis of results of a single epidemiologic study that, while drawing on a large group (17,077), included only 22 girls with true precocious puberty, Dr.
Diagnosis of true precocious puberty was defined as the presence of both breast and pubic hair development before the age of 8 with a concomitant growth spurt.
We don't know why true precocious puberty
occurs in many of the girls.
Of those, 47% (105) had two signs of puberty, consistent with true precocious puberty
, while 12% also had other endocrine diagnoses, most commonly hypothyroidism or hyperinsulinism (Pediatrics 111:47-51,2003).
In true precocious puberty
, breast budding or pubic hair development is accompanied by accelerated growth, advancement of bone age, and adult genital features.