trospium


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Related to trospium: Trospium chloride, Sanctura

trospium

(tros-pee-yum) ,

Sanctura

(trade name),

Sanctura XR

(trade name),

Trosec

(trade name)

Classification

Therapeutic: urinary tract antispasmodics
Pharmacologic: antimuscarinics
Pregnancy Category: C

Indications

Overactive bladder with symptoms of urge urinary incontinence, urgency and urinary frequency.

Action

Antagonizes the effect of acetylcholine at muscarinic receptors in the bladder; this parasympatholytic action reduces bladder smooth muscle tone.

Therapeutic effects

Increased bladder capacity and decreased symptoms of overactive bladder.

Pharmacokinetics

Absorption: Less than 10% absorbed following oral administration; food significantly ↓ absorption.
Distribution: Mostly distributed to plasma.
Metabolism and Excretion: Of the 10% absorbed, 40% is metabolized. Unabsorbed drug is mainly excreted in feces. Of absorbed drug, 60% is eliminated in urine as unchanged drug via active tubular secretion.
Half-life: 20 hr.

Time/action profile (anticholinergic effects)

ROUTEONSETPEAKDURATION
POunknown5–6 hr24 hr

Contraindications/Precautions

Contraindicated in: Hypersensitivity;Gastric or urinary retention, uncontrolled angle-closure glaucoma or risk for these conditions.
Use Cautiously in: Bladder outflow obstruction;Gastrointestinal obstructive disorders (ulcerative colitis, intestinal atony, myasthenia gravis);Controlled angle-closure glaucoma (use only if necessary and with careful monitoring);CCr <30 mL/min (dose ↓ recommended);Moderate to severe hepatic impairment; Obstetric / Lactation: Use only if benefit justifies risks to fetus/newborn; Pediatric: Safety not established; Geriatric: May have↑ sensitivity to anticholinergic effects; ↓ dose may be required.

Adverse Reactions/Side Effects

Central nervous system

  • headache (most frequent)
  • confusion
  • dizziness
  • drowsiness
  • fatigue
  • hallucinations

Ear, Eye, Nose, Throat

  • blurred vision

Gastrointestinal

  • constipation (most frequent)
  • dry mouth (most frequent)
  • dyspepsia

Genitourinary

  • urinary retention
  • urinary tract infection

Miscellaneous

  • angioedema (life-threatening)
  • fever
  • heat stroke

Interactions

Drug-Drug interaction

May interact with other drugs that compete for tubular secretion.Metformin may ↓ levels.↑ risk of anticholinergic effects with other drugs having anticholinergic properties.

Route/Dosage

Oral (Adults) 20 mg twice daily or 60 mg once daily (XR dose form).
Oral (Adults ≥75 yr) Based on tolerability, dose may be ↓ to 20 mg once daily.

Renal Impairment

Oral (Adults) CCr <30 mL/min—20 mg once daily at bedtime.

Availability (generic available)

Tablets: 20 mg
Extended release tablets: 60 mg

Nursing implications

Nursing assessment

  • Monitor voiding pattern and intake and output ratios.

Potential Nursing Diagnoses

Impaired urinary elimination (Indications)

Implementation

  • Oral: Administer 1 hr prior to meals or on an empty stomach.

Patient/Family Teaching

  • Instruct patient to take as directed. If a dose is skipped, take next dose 1 hr prior to next meal.
  • May cause drowsiness, dizziness, and blurred vision. Caution patient to avoid driving and other activities requiring alertness until response to medication is known. Advise patient to avoid alcohol; may increase drowsiness.
  • Advise patient to notify health care professional immediately of signs and symptoms of angioedema (edema of the tongue or laryngopharynx, difficulty breathing) occur.
  • Caution patient that heat prostration (fever and heat stroke due to decreased sweating) may occur when trospium is taken in a hot environment.
  • Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected, or if breast feeding.

Evaluation/Desired Outcomes

  • Increased bladder capacity and decreased symptoms of overactive bladder.

trospium

an anticholinergic.
indication This drug is used to treat overactive bladder.
contraindications Uncontrolled narrow-angle glaucoma, urinary retention, gastric retention, and known hypersensitivity to this drug prohibit its use.
adverse effects Adverse effects of this drug include fatigue, dizziness, headache, dry eyes, vision abnormalities, flatulence, abdominal pain, and dyspepsia. Common side effects include constipation and dry mouth.
References in periodicals archive ?
Instead of trospium chloride, the microspheres are loaded with barium sulfate, which enables the analysis of the microstructure with a micro-computer tomography scanner ([micro]CT).
Karuna believes that the addition of trospium chloride may reduce the side effects typically seen with xanomeline alone.
Failure Oxybutynin (Ditropan) 5 mg, 2-3 times per day to store Tolterodine 4 mg, daily (Detrusitol SR) Trospium (Uricon) 20 mg, twice daily Darifenacin(Enablex) 7.
Darifenacin, oxybutynin, solifenacin, tolterodine, and trospium are indicated for the treatment of OAB with symptoms of urge urinary incontinence, urgency, and urinary frequency (3-13).
Pharmacotherapy (anticholinergic medication) includes any form of oxybutynin, tolterodine, trospium chloride, solfenacin, or darifenacin.
Madaus has a varied product portfolio targeting urology, including proprietary products such as Trospium Chloride.
The company's core products under development include trospium for overactive bladder, pagoclone for panic/anxiety disorders, citicoline for ischemic stroke, IP 751 for pain and inflammation, and PRO 2000 for the prevention of infection by HIV and other sexually transmitted pathogens.
The ingestion of enalapril, trospium chloride, and a ginkgo biloba preparation (Tebonin intens[R]; Dr.
The same or a slightly smaller percentage of surveyed urologists selected darifenacin (Novartis/Bayer's Enablex/Emselex), ER trospium chloride (Allergan/Madaus/Speciality European Pharma/Rottapharm's Sanctura XR/Urivesc/Regurin XR, generics) or ER oxybutynin (McNeil/Janssen-Cilag's Ditropan XL/Lyrinel XL, generics) as the most efficacious drug for the indication.
Contract notice: Completion of a non-exclusive discount agreement pursuant to A* 130 para 8 sgb v to the active ingredient trospium -.
3] Seven different anticholinergics are currently marketed for the treatment of DO/NDO in adults (oxybutynin, tolterodine, trospium, darifenacin, solifenacin, propiverine and fesoterodine), but none of them has been shown superior to another.
According to a 2010 review from the Agency for Healthcare Quality and Research, options include the antimuscarinic drugs tolterodine, trospium, solifenacin, darife-nacin, and fesoterodine.