troponin T


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troponin T

A protein, found in both skeletal and cardiac muscle, that can be detected in the blood following injury to heart muscle. Assays for it can be used as rapid tests for myocardial infarction (MI). Troponin I (which is released only by heart and not by skeletal muscles) is a more specific marker for MI than troponin T.
See also: troponin
References in periodicals archive ?
HOURS FROM ONSET OF CHEST PAIN SENSITIVITY SPECIFICITY Troponin T >0.1(*) 1 0.47 0.87 2 0.53 0.87 3 0.58 0.86 4 0.64 0.85 6 0.74 0.83 8 0.84 0.81 10 0.93 0.80 Troponin T >0.2([dagger]) 1 0.14 0.87 2 0.33 0.87 3 0.50 0.86 4 0.65 0.85 6 0.86 0.83 8 0.96 0.81 10 0.96 0.80 Troponin 1 >0.1([double dagger]) 1 0.13 0.95 2 0.34 0.95 3 0.52 0.95 4 0.67 0.95 5 0.80 0.95 6 0.90 0.95 LR+ LR- Troponin T >0.1(*) 3.7 0.6 3.9 0.5 4.1 0.5 4.2 0.4 4.4 0.3 4.5 2.0 4.6 0.1 Troponin T >0.2([dagger]) 1.1 1.0 2.5 0.8 3.5 0.6 4.3 0.4 5.1 0.2 5.2 0.1 4.7 0.1 Troponin 1 >0.1([double dagger]) 2.7 0.9 6.8 0.7 10 5.0 13 0.3 16 0.2 18 0.1 NOTE: Values are calculated from the best-fit curves for sensitivity and specificity shown in Figure
[2] Nonstandard abbreviations: cTnT, cardiac troponin T; cTnI, cardiac troponin I; AMI, acute myocardial infarction; ACS, acute coronary syndromes; TnC, troponin C; HAMA, human antimouse antibodies.
[4] Nonstandard abbreviations: CK, creatine kinase; RI, reference interval; cTnT, cardiac troponin T; hs-cTnT, high-sensitivity cTnT; cTnI, cardiac troponin I; hs-cTnI, high-sensitivity cTnI; CMR, cardiac magnetic resonance imaging; MADD, multiple acyl-CoA dehydrogenase deficiency.
By combining clinical information and EKG findings with H-FABP and high-sensitivity cardiac troponin T (hs-cTnT) concentrations, the Manchester Acute Coronary Syndromes (MACS) clinical prediction model can stratify patients with acute chest pain into 4 risk groups.
Incremental value of high-sensitive troponin T in addition to the revised cardiac indexfor peri-operative riskstratification in non-cardiac surgery.
Age- and sex-dependent upper reference limits for the high-sensitivity cardiac troponin T assay.
Troponin T measurements at enrollment were examined for use in risk stratification in a GUSTO IIa substudy, using an outcome of 30-day mortality for 801 patients with acute coronary syndromes.[28] For these patients, troponin T measurement was an independent risk factor that demonstrated a larger contribution for predicting 30-day mortality than either ECG category or CK-MB mass result.
Innovative technology such as mini-column separation methods (in the '70s and early '80s) for quantitative measurement of CK-MB and automated electrophoretic separation of CK-MB into two isoforms (in the '90s) have played vital roles in the development of our current automated enzyme immunoassays, which utilize highly sensitive and specific monoclonal antibodies to capture and detect CK-MB, myoglobin, troponin T, and troponin I.
Neumann, M.D., from the University Heart Center Hamburg in Germany, and colleagues determined the concentrations of high-sensitivity troponin I or high-sensitivity troponin T in 15 international cohorts of patients with symptoms suggestive of myocardial infarction; troponin was measured at presentation to the emergency department and after early or late serial sampling.
The 5th generation Troponin T assay, commonly referred to as "high sensitivity Troponin" or hs-cTnT, has been validated and used for several years in many countries, primarily in Europe and Australia, but was only recently approved by the FDA for use in the United States.
Cardiac Troponin T is a sensitive, specific biomarker of cardiac injury in laboratory animals.