troponin


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troponin

 [tro´po-nin]
a complex of muscle proteins which, when combined with Ca++, influence tropomyosin to initiate contraction.

tro·po·nin

(trō'pō-nin),
A globular protein of muscle that binds to tropomyosin and has considerable affinity for calcium ions; a central regulatory protein of muscle contraction. Troponin T binds to tropomyosin; troponin I inhibits F-actin-myosin interactions; troponin C is a calcium-binding protein and has a key role in muscle contraction.

troponin

/tro·po·nin/ (tro´po-nin) a complex of muscle proteins which, when combined with Ca2+, influence tropomyosin to initiate contraction.

troponin

(trō′pə-nĭn, trŏp′ə-)
n.
A calcium-regulated protein, composed of three subunits, that is found in skeletal and cardiac muscle and regulates contraction by interacting with tropomyosin to control the binding of myosin to actin. Blood troponin levels are a biomarker for muscle damage, as in myocardial infarction.

troponin

[trō′pənin]
Etymology: Gk, trepein, to turn
a protein in the striated cell ultrastructure that modulates the interaction between actin and myosin molecules. It is believed to be part of the calcium-binding complex of the thin myofilaments. See also tropomyosin.

tro·po·nin

(Tn) (trō'pō-nin)
A complex of three proteins, troponin-C (TnC), troponin-I (TnI), troponin-T (TnT), and present in striated muscle. Together, these proteins function as regulators of muscle contraction. Several isoforms exist. The cardiac isoform of TnT is specific for cardiac muscle; the blood level of TnT rises within 4 hours after myocardial damage and remains elevated for 10-14 days after an acute myocardial infarction (MI). Measurement of this protein is valuable in the early diagnosis of MI and in monitoring the effectiveness of thrombolytic therapy after an MI.

troponin

A regulatory protein in striated muscle bound to TROPOMYOSIN and ACTIN in thin filaments. Troponin is the site of calcium binding that starts the contraction of the SARCOMERE.

troponin

a complex of calcium-binding proteins that allows TROPOMYOSIN to move out of the myosin-blocking situation on muscle actin filaments.

troponin

a complex of muscle proteins which, when combined with Ca2+, influence tropomyosin to initiate contraction.
References in periodicals archive ?
Implications of introducing high-sensitivity cardiac troponin T into clinical practice: data from the SWEDEHEART Registry.
5 times more likely to have increased troponin levels of at least 14 nanograms per litre, indicating heart damage.
No research, however, had ever examined whether sitting was associated with high troponin levels.
A quarter of the patients with troponin levels of 50 nanograms per litre (ng/l) or above before surgery died within six months, researchers found.
Chi-square test was used to evaluate the relation between cardiac troponin I levels and CAD extent, properties and Syntax Score in the two groups of cardiac troponin I.
2% overall had troponin autoantibodies with similar prevalence in patients with or without myocardial infarction (6).
ii) Investigate the relationship between cardiac troponin T and severity and location of a stroke.
The patients in our study were not having symptoms of a heart attack, and yet a remarkably high proportion of them had an abnormal troponin, suggesting they were experiencing ongoing injury to their hearts," says lead author Brendan Everett, MD, MPH.
These findings "raise the possibility that serial measurements of troponin concentration may improve its prognostic value, and that persistently elevated and increasing troponin concentrations may be the best predictor of adverse outcomes," said Dr.
Troponin and tropomyosin are indispensable for the physiological regulation of striated muscle contraction.
The company said the Meritas Troponin I product is now demonstrating the identical clinical performance witnessed in its European CE marking trials early in 2014 and in the independent clinical evaluation carried out at Hennepin County Medical Centre, Minneapolis and published at the AACC meeting in July 2014.
Few published studies have shown that current troponin assays have different susceptibilities to interference by hemolysis.