troponin


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Related to troponin: Troponin T, Cardiac enzymes, cardiac troponin T

troponin

 [tro´po-nin]
a complex of muscle proteins which, when combined with Ca++, influence tropomyosin to initiate contraction.

tro·po·nin

(trō'pō-nin),
A globular protein of muscle that binds to tropomyosin and has considerable affinity for calcium ions; a central regulatory protein of muscle contraction. Troponin T binds to tropomyosin; troponin I inhibits F-actin-myosin interactions; troponin C is a calcium-binding protein and has a key role in muscle contraction.

troponin

/tro·po·nin/ (tro´po-nin) a complex of muscle proteins which, when combined with Ca2+, influence tropomyosin to initiate contraction.

troponin

(trō′pə-nĭn, trŏp′ə-)
n.
A calcium-regulated protein, composed of three subunits, that is found in skeletal and cardiac muscle and regulates contraction by interacting with tropomyosin to control the binding of myosin to actin. Blood troponin levels are a biomarker for muscle damage, as in myocardial infarction.

troponin

[trō′pənin]
Etymology: Gk, trepein, to turn
a protein in the striated cell ultrastructure that modulates the interaction between actin and myosin molecules. It is believed to be part of the calcium-binding complex of the thin myofilaments. See also tropomyosin.

tro·po·nin

(Tn) (trō'pō-nin)
A complex of three proteins, troponin-C (TnC), troponin-I (TnI), troponin-T (TnT), and present in striated muscle. Together, these proteins function as regulators of muscle contraction. Several isoforms exist. The cardiac isoform of TnT is specific for cardiac muscle; the blood level of TnT rises within 4 hours after myocardial damage and remains elevated for 10-14 days after an acute myocardial infarction (MI). Measurement of this protein is valuable in the early diagnosis of MI and in monitoring the effectiveness of thrombolytic therapy after an MI.

troponin

A regulatory protein in striated muscle bound to TROPOMYOSIN and ACTIN in thin filaments. Troponin is the site of calcium binding that starts the contraction of the SARCOMERE.

troponin

a complex of calcium-binding proteins that allows TROPOMYOSIN to move out of the myosin-blocking situation on muscle actin filaments.

troponin

a complex of muscle proteins which, when combined with Ca2+, influence tropomyosin to initiate contraction.
References in periodicals archive ?
A biochemical test for use as an adjunct to the electrocardiogram and troponin blood test, to rule out MI in patients presenting to the emergency department with chest pain.
Decline of cardiac troponin I values was followed over a mean ([+ or -] SD) of 2.
Troponin can be used to identify stable patients at high risk for deadly cardiac events, according to a new study led by researchers at Brigham and Women's Hospital.
Moreover, an increase of more than 25% in troponin T level during the course of 1 year predicts a worse outcome than do stable or decreasing troponin T levels in this patient population, significantly increasing the rates of death from cardiovascular causes, MI, or stroke.
A primary focus was to ensure that the suggested protocols also apply to high-sensitivity cardiac troponin assays.
The troponin test is used to help diagnose a heart attack, stroke, TIA's, blood thinning/clotting, determining if the heart is ok for blood thinning medications, to detect and evaluate mild to severe heart injury, and to distinguish chest pain that may be due to other causes.
Firstly, of unselected patients aged [greater than or equal to] 45 years undergoing non-cardiac surgery, over 11% are expected to have a prognostically important postoperative troponin leak.
Our study specifically investigates the impact of pre-existing cardiac history and troponin I elevations in surgical patients with severe sepsis or septic shock treated with a pulmonary artery catheter.
6,18) The total imprecision (coefficient of variation) around the upper reference limits of the 2 troponin assays, monitored in our routine practice with 2 different pooled human serum samples, was less than 13% for cTnT (mean concentration, 0.
The abnormality was most pronounced in the athletes with the highest troponin concentrations.
The novel Troponin I variant was one of a group of putative cancer and cardiovascular biomarkers previously predicted by Compugen's immunoassay biomarker computational discovery platform.
The findings of this study add to the accumulating data that suggest cardiac troponin testing may become routine for risk stratification across the entire spectrum of ischemic heart disease.