troponin


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troponin

 [tro´po-nin]
a complex of muscle proteins which, when combined with Ca++, influence tropomyosin to initiate contraction.

tro·po·nin

(trō'pō-nin),
A globular protein of muscle that binds to tropomyosin and has considerable affinity for calcium ions; a central regulatory protein of muscle contraction. Troponin T binds to tropomyosin; troponin I inhibits F-actin-myosin interactions; troponin C is a calcium-binding protein and has a key role in muscle contraction.

troponin

(trō′pə-nĭn, trŏp′ə-)
n.
A calcium-regulated protein, composed of three subunits, that is found in skeletal and cardiac muscle and regulates contraction by interacting with tropomyosin to control the binding of myosin to actin. Blood troponin levels are a biomarker for muscle damage, as in myocardial infarction.

tro·po·nin

(Tn) (trō'pō-nin)
A complex of three proteins, troponin-C (TnC), troponin-I (TnI), troponin-T (TnT), and present in striated muscle. Together, these proteins function as regulators of muscle contraction. Several isoforms exist. The cardiac isoform of TnT is specific for cardiac muscle; the blood level of TnT rises within 4 hours after myocardial damage and remains elevated for 10-14 days after an acute myocardial infarction (MI). Measurement of this protein is valuable in the early diagnosis of MI and in monitoring the effectiveness of thrombolytic therapy after an MI.

troponin

A regulatory protein in striated muscle bound to TROPOMYOSIN and ACTIN in thin filaments. Troponin is the site of calcium binding that starts the contraction of the SARCOMERE.

troponin

a complex of calcium-binding proteins that allows TROPOMYOSIN to move out of the myosin-blocking situation on muscle actin filaments.
References in periodicals archive ?
Multicenter evaluation of a 0-hour/1-hour algorithm in the diagnosis of myocardial infarction with high-sensitivity cardiac troponin T.
The findings highlight the potential utility of high-sensitivity cardiac troponin in both clinical trials and clinical practice, according to researcher Nicholas L.
A body of research has shown that measuring a person's troponin levels using the company's High Sensitive Troponin-I test provides better predictive information for determining a person's chances of developing future heart disease when added to the current standard of care.
The concentration of cardiac troponin I were higher in dogs with cardiogenic respiratory distress in comparison to primary respiratory disorders.
All patients in the first study (the observational study) were treated according to standard care, which included ECG and cTn1 measurements at presentation, followed by troponin measurements 6 h later (93.4% of all patients).
The patient's blood sample was tested with different immunoassays (Elecsys Troponin I and T Assay, Roche), which revealed undetectable cTnI and cTnT levels.
Implications of introducing high-sensitivity cardiac troponin T into clinical practice: data from the SWEDEHEART Registry.
Results: Median value of high sensitivity troponin I was 4.051ng/ml before re-centrifugation and 3.689 ng/ml after recentrifugation.
This idea of troponin release (from exercise) has been well described," said Khera, who was not involved in the new study but serves as an editor of Circulation.
Neumann, M.D., from the University Heart Center Hamburg in Germany, and colleagues determined the concentrations of high-sensitivity troponin I or high-sensitivity troponin T in 15 international cohorts of patients with symptoms suggestive of myocardial infarction; troponin was measured at presentation to the emergency department and after early or late serial sampling.
'We're finding that people's weight from age 25 onwards is linked to the risk of more or less heart damage, as measured by levels of the protein troponin, later in life, which underscores the likely importance of long-term weight control for reducing heart disease risk,' said Chiadi Ndumele, Assistant Professor at the Johns Hopkins University.
Summary: A new study has shown that sitting was more strongly associated with unhealthy levels of troponin, proteins produced by cardiac-muscle cells when they are hurt or dying