tropomyosin


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tropomyosin

 [tro″po-mi´o-sin]
a muscle protein of the I band that inhibits contraction by blocking the interaction of actin and myosin, except when influenced by troponin.

tro·po·my·o·sin

(trō'pō-mī'ō-sin),
A fibrous protein extractable from muscle; sometimes specified as tropomyosin B to distinguish it from tropomyosin A (paramyosin) prominent in mollusks.

tropomyosin

(trō′pə-mī′ə-sĭn, trŏp′ə-)
n.
A protein that binds to and stabilizes actin filaments in cells. In skeletal and cardiac muscle cells, tropomysin is released after interacting with troponin and calcium, facilitating the binding of actin to myosin that causes muscle contraction.

tro·po·my·o·sin

(trō'pō-mī'ŏ-sin)
A fibrous protein extractable from muscle; sometimes specified as tropomyosin B to distinguish it from tropomyosin A (paramyosin) prominent in mollusks.

tropomyosin

A regulatory protein in striated muscle concerned with the binding sites for the cross bridges on thin filaments in the SARCOMERE. Tropomyosin reversibly prevents bonding, thereby preventing muscles form being in a continuous state of contraction.

tropomyosin

a long protein molecule found in the grooves of muscle ACTIN filaments. It inhibits muscle contraction by blocking the interaction between the filaments and MYOSIN.
References in periodicals archive ?
Caption: Figure 4: Densitometric profile and SDS-PAGE of a pool of 15 myofibrillar extracts obtained from sole, European hake, and sea bass samples extracted with denaturing (a) and nondenaturing (b) solutions (1 = myosin heavy chain; 2 = 180-110 kDa; 3 = [alpha]-actinin; 4 = 95-55 kDa; 5 = desmin; 6 = 51-47 kDa; 7 = actin; 8 = 40-38 kDa; 9 = tropomyosin; 10 = 33-23 kDa; 11 = myosin light chain 1; 12 = 21-18 kDa; 13 = 16 kDa; 14 = myosin light chain 2; 15 = 14-10 kDa).
DAMP: danger-associated molecular pattern; DC: dendritic cell; FLT3-L: fms-like tyrosine kinase 3-ligand; ILT7: inhibitory receptor Ig-like transcript 7; pDC: plasmacytoid DC; TRKA: tropomyosin receptor kinase A.
Mutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients.
(13) Both of troponin and tropomyosin are essential for the calcium-regulation of striated muscle.
Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignancies.
Moreover, the denaturation of myosin has been linked with the dissociation of other adjacent proteins such as actin, troponin, and tropomyosin within the acto-myosin cross bridge complex.
Of the two forms, especially in UC, an autoantigen named human tropomyosin isolated form 5 (hTM5) plays an important role in the activation of humoral and cellular mediated responses [35].
Forced expression of miR-21 increases proliferation and invasion of PDAC cell lines, and this appears to occur through target inhibition of the phosphatase and tensin homolog (PTEN), programmed cell death 4 (PDCD4), presence of tropomyosin 1 (TPM1), and tissue inhibition of metalloproteinases-3 (TIMP3), thereby indirectly inducing expression of matrix metalloproteinase-2 and -9 and vascular endothelial growth factor (VEGF).
Olsen, "Detection of tropomyosin and determination of proteins in crustacean oils," Food Chemistry, vol.
An altered dynamicity of tropomyosin in heart versus skeletal muscle may contribute to higher concentration of TPM1[alpha] mRNA observed in skeletal muscle.