Allergic symptoms were promoted within 30 min after tropomyosin
Caption: Figure 4: Densitometric profile and SDS-PAGE of a pool of 15 myofibrillar extracts obtained from sole, European hake, and sea bass samples extracted with denaturing (a) and nondenaturing (b) solutions (1 = myosin heavy chain; 2 = 180-110 kDa; 3 = [alpha]-actinin; 4 = 95-55 kDa; 5 = desmin; 6 = 51-47 kDa; 7 = actin; 8 = 40-38 kDa; 9 = tropomyosin
; 10 = 33-23 kDa; 11 = myosin light chain 1; 12 = 21-18 kDa; 13 = 16 kDa; 14 = myosin light chain 2; 15 = 14-10 kDa).
DAMP: danger-associated molecular pattern; DC: dendritic cell; FLT3-L: fms-like tyrosine kinase 3-ligand; ILT7: inhibitory receptor Ig-like transcript 7; pDC: plasmacytoid DC; TRKA: tropomyosin
receptor kinase A.
Mutations in repeating structural motifs of tropomyosin
cause gain of function in skeletal muscle myopathy patients.
(13) Both of troponin and tropomyosin
are essential for the calcium-regulation of striated muscle.
Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin
receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignancies.
Moreover, the denaturation of myosin has been linked with the dissociation of other adjacent proteins such as actin, troponin, and tropomyosin
within the acto-myosin cross bridge complex.
Of the two forms, especially in UC, an autoantigen named human tropomyosin
isolated form 5 (hTM5) plays an important role in the activation of humoral and cellular mediated responses .
Forced expression of miR-21 increases proliferation and invasion of PDAC cell lines, and this appears to occur through target inhibition of the phosphatase and tensin homolog (PTEN), programmed cell death 4 (PDCD4), presence of tropomyosin
1 (TPM1), and tissue inhibition of metalloproteinases-3 (TIMP3), thereby indirectly inducing expression of matrix metalloproteinase-2 and -9 and vascular endothelial growth factor (VEGF).
Olsen, "Detection of tropomyosin
and determination of proteins in crustacean oils," Food Chemistry, vol.
An altered dynamicity of tropomyosin
in heart versus skeletal muscle may contribute to higher concentration of TPM1[alpha] mRNA observed in skeletal muscle.