The contract has been signed to provide a continued specialised compound prescription of Homatropine in a novel oral suspension, Tropine
3, to support planned FDA compliant Clinical trial participants.
The toxin was unknown in 131 (5%) incidents; 49 presented with extrapyramidal dystonic reactions responsive to tropine
alkaloid (biperiden) management.
The plant contains alkaloids including tropine
, pseudotropine, isopelletierine and anaferine (Dhuley 1997).
(1-4) The tropine
alkaloids inhibit acetylcholine receptors in the brain and parasympathetic nervous system, producing a classic toxidrome of flushed, dry skin, lowgrade fever, tachycardia, mydriasis, ileus, urinary retention, agitation, vertigo, and dysphoria; later progressing to aggression, confusion, dysarthria, hallucinations, and, potentially fatal coma.
Pristine Solutions holds the intellectual property and global marketing rights to Tropine
3, a patent pending novel indication of an existing FDA approved drug for the non- hormonal treatment of hot flashes in pre-menopausal, peri- menopausal and post-menopausal women, through Eaton Scientific Systems.
Then, compounds with higher affinity for muscarinic receptors were synthesized by introducing a tropine
or quinuclidinyl group instead of a piperazine group (Nos.
Biosynthesis of tropine
moiety of hyoscyamine from D-N-methylornithine.