tropicamide


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Related to tropicamide: homatropine, Cyclopentolate

tropicamide

Mydriacyl® Ophthalmology An antichoinergic that blocks the action of acetylcholine, dilating the pupils in Alzheimer's disease–AD Pts in a highly diluted concentrations, a finding that some authors believe may be of use as a clinical test for AD; probably not

tropicamide

A drug used in the form of eye drops to widen (dilate) the pupil so that the inside of the eye can more easily be examined or operated upon. The drug is on the WHO official list. Brand names are Minims tropicamide and Mydriacyl.

acetylcholine (ACh) 

A neurotransmitter substance with special excitatory properties of all preganglionic autonomic neurons, all parasympathetic postganglionic neurons and a few postganglionic sympathetic neurons. Acetylcholine is synthesized and liberated by the action of the enzyme choline acetyltranferase from the compounds choline and acetyl coenzyme A (acetyl CoA) which occurs in all cholinergic neurons. ACh exists only momentarily after its formation, being hydrolysed by the enzyme acetylcholinesterase which is present in the neurons of cholinergic nerves throughout their entire lengths and at neuromuscular junctions: this process is essential for proper muscle function as otherwise the accumulation of ACh would result in continuous stimulation of the muscles, glands and central nervous system. Alternatively a shortage of ACh has devastating effect (e.g. myasthenia gravis). ACh binds to acetylcholine receptors on skeletal muscle fibres. Sodium enters the muscle fibre membrane, which leads to a depolarization of the membrane and muscle contraction. There are two main types of acetylcholine receptors (cholinergic receptors): muscarinic receptors, which are stimulated by muscarine and ACh, belong to a family of G proteins coupled receptors and are situated in parasympathetically innervated structures (e.g. the iris and ciliary body); and nicotine receptors, which are stimulated by nicotine and ACh, are ligand-gated receptors and are situated in striated muscles (e.g. the extraocular muscles). Cholinergic receptors are found in the sympathetic and parasympathetic nervous systems, in the brain and spinal cord. The action of ACh can be either blocked or stimulated by drugs: Anticholinesterase drugs (e.g. neostigmine) inhibit acetylcholinesterase and prolong the action of acetylcholine whereas antimuscarinic drugs (also referred to as anticholinergics or parasympatholytics) such as atropine, cyclopentolate, homatropine, hyoscine and tropicamide inhibit the action of acetylcholine at muscarinic receptors. Other drugs mimic the action of ACh, they are known as parasympathomimetics (e.g. pilocarpine). See cholinergic; cycloplegia; miotics; mydriatic; neurotransmitter; nicotine; synapse; autonomic nervous system.

cycloplegia 

Paralysis of the ciliary muscle resulting in a loss of accommodation. It is usually accompanied by dilatation of the pupil. See acetylcholine; anisocycloplegia; latent hyperopia; mydriatic.

mydriatic

1. Causing mydriasis of the pupil. 2. A drug which produces mydriasis. Mydriatics are used to carry out a thorough inspection of the fundus and lens, especially in elderly patients in whom the pupils are usually smaller. However, in older people it must be ascertained that the patient does not have glaucoma. There are two classes of mydriatics: (1) antimuscarinic (parasympatholytic, anticholinergic, atropine-like) drugs which antagonize the action of acetylcholine at muscarinic receptors in the ciliary muscle, such as atropine, cyclopentolate, homatropine, hyoscine (scopolamine) and tropicamide. Antimuscarinic drugs produce cycloplegia as well. (2) sympathomimetic (adrenergic stimulating) drugs which directly or indirectly stimulate the dilator pupillae muscle which is innervated by the sympathetic division of the autonomic nervous system. These include cocaine, ephedrine hydrochloride, adrenaline (epinephrine), naphazoline and phenylephrine hydrochloride. See adrenergic receptors; cholinergic; cycloplegia; miotics; dilator pupillae muscle; mydriasis; pupil light reflex; sympathomimetic.

tropicamide

a rapid-acting parasympatholytic agent used topically as a mydriatic for ophthalmoscopic examination.
References in periodicals archive ?
Furthermore, pupils seem to become sensitive to tropicamide very early in the course of the disease.
Adequate cycloplegic effect could be achieved with tropicamide in a teenage patient suspected of having latent hypermetropia, for example, whereas cyclopentolate is likely to be required for an infant suspected of having an accommodative esotropia.
27) To achieve adequate dilation to examine the retina in patients with DM, one study suggests using a combination of the topical drugs tropicamide and phenylephrine.
The pupil is dilated with 1% tropicamide and anesthetised with proxymetacaine.
Optometrists are well aware of the risk of angle closure with anti-muscarinic drugs such as tropicamide, however several systemic drugs have similar anti-cholinergic properties eg anti-depressants, anti-anxiety agents and anti-histamines.
In our previous article, (1) a one-way ANOVA in a randomised design was applied to an optometric experiment designed to compare the effect of the drug Tropicamide on the degree of pupil dilation in a group of control subjects, a group of patients diagnosed with Alzheimer's disease (AD), and a group of patients diagnosed with dementia other than AD.