tropical splenomegaly syndrome

tropical splenomegaly syndrome

An idiopathic splenomegaly affecting malnourished children and adult ♀ in malaria-endemic regions–eg, New Guinea, Africa, which may be a defective immune response to P malariae Clinical Massive splenomegaly, asthenia, fatigue Lab ↑ IgM antibodies against P vivax, ↓ T-helper cells ↓ CD4:CD8 ratio Treatment Chloroquine

hy·per·re·ac·tive ma·lar·i·ous sple·no·meg·a·ly

(hī'pĕr-ak'tiv mă-lar'ē-ŭs splē'nō-meg'ă-lē)
A syndrome characterized by persistent splenomegaly, exceptionally high serum IgM and malaria antibody levels, and hepatic sinusoidal lymphocytosis.
Synonym(s): tropical splenomegaly syndrome.
References in periodicals archive ?
Reduction of suppressor T lymphocytes in the tropical splenomegaly syndrome.
TROPICAL SPLENOMEGALY SYNDROME (TTS): is seen in people living in the malaria endemic area.