Among the GCNIS-derived tumors, the trophoblastic category has undergone a substantial revision in the current WHO classification, which now adds 2 additional forms under the nonchoriocarcinomatous trophoblastic tumors--epithelioid trophoblastic tumor
and cystic trophoblastic tumor--to the previously established entity placental site trophoblastic tumor
Gestational trophoblastic disease (GTD) is a spectrum of disorders extending from premalignant conditions of hydatidiform mole, which can be further classified into partial (PHM) and complete (CHM) hydatidiform mole, to malignant conditions including invasive mole, choriocarcinoma, and placental site trophoblastic tumor
There are also specific recommendations for treatment of two even rarer intermediate trophoblastic tumor
types: placental-site trophoblastic tumor
and epithelioid trophoblastic tumor
Placental site trophoblastic tumor
(PSTT) constitutes about 1-2% of all trophoblastic tumors
Gestational trophoblastic disease is a group of disorders caused by the overgrowth of placental tissue and is defined as the spectrum of disease that has at one extreme the benign hydatidiform mole which could be complete or partial mole, the locally Invasive mole, Placental site trophoblastic tumor
, Gestational tropho-blastic neoplasia and at the other end, the highly malignant Choriocarcinoma, based on genetic and histopathological features1.
It is important to mention that choriocarcinoma was demonstrated in the biopsy in only 50% of the patients with these [beta]-hCG levels; therefore, CS can exist in patients without a recognized trophoblastic tumor
Between July 22, 2015 and December 31, 2016, 48 patients were accrued with previously treated metastatic urothelial carcinoma (mUC, n=19), urachal adenocarcinoma, squamous cell carcinoma of the bladder or urethra, germ cell tumor, castration-resistant prostate cancer, renal cell carcinoma, trophoblastic tumor
, sertoli cell tumor or penile squamous cell carcinoma and treated in two parts.
Gestational trophoblastic disease describes a number of gynecologic tumors that originate in trophoblastic layer including hydatidiform mole (complete or partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor
and epitheloid trophoblastic tumor
Epithelioid trophoblastic tumor
: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor
As a matter of fact, gestational trophoblastic tumor
is disease of reproductive age group, rarely seen after fifth decade.
Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors
, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor
Gestational trophoblastic disease (GTD) refers to an abnormal trophoblastic proliferation composed of a broad spectrum of lesions ranging from benign, albeit premalignant hydatiform mole (complete and partial), through to the aggressive invasive mole, choriocarcinoma, and placental site trophoblastic tumor