trophoblastic disease


Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia.

trophoblastic disease

,

TD

Any neoplasm of trophoblastic origin.
See: chorioadenoma destruens; choriocarcinoma; hydatid mole
References in periodicals archive ?
Recent advances in gestational trophoblastic disease.
Gestational trophoblastic disease (GTD) or placental site trophoblastic site disease (PSTD) can also have very similar MRI features to that of RPOC.
7) Since multiple forms of hCG characterize gestational-trophoblastic diseases such as regular and hyperglycosylated hCG, it is important for physicians managing gestational trophoblastic disease cases to make sure that an appropriate total hCG test is being used by the testing laboratory.
Clinical information was available for 96 of the samples: 46 from patients with gestational trophoblastic disease, of which 76% were positive (>5 IU/L); 35 with germ-cell tumors (80% positive); 8 with unspecified gonadal tumors (50% positive); and 7 with other cancers (71% positive).
The splitters want to have separate assays that are highly specific for the different variants because the type of variant or the ratios of some the variants to each other may provide some additional diagnostic information, such as the differentiation of benign or malignant trophoblastic disease.
Of the 23 patients with hCG of placental origin, 17 had resolving abortion/miscarriage, 4 had gestational trophoblastic disease, and two were early in pregnancy.
Radioimmunoassay of the serum free beta-subunit of human chorionic gonadotropin in trophoblastic disease.
High levels of hCG indicate pregnancy, but in absence of pregnancy can be an indicator of serious medical conditions including a rare form of cancer called trophoblastic disease.
Such cases have 3 potential etiologies: (a) false-positive hCG due to interfering antibodies, (b) quiescent gestational trophoblastic disease, and (c) pituitary hCG.
Malignancy Marker(s) Nonseminomatous germ AFP; (a) HCG cell cancer Trophoblastic disease HCG Ovarian cancer CA 125 Colorectal cancer CEA Prostate cancer PSA Malignancy Use of marker(s) Reference Nonseminomatous germ Prognosis, surveillance, and (1) cell cancer monitoring of therapy Trophoblastic disease Surveillance and monitoring of (2) treatment Ovarian cancer Monitoring of therapy (3) Colorectal cancer Surveillance and monitoring of (4) therapy Prostate cancer Prognosis, surveillance, and (5) monitoring of therapy (a) AFP, [alpha]-fetoprotein; HCG, human chorionic gonadotropin; PSA, prostate-specific antigen.
These are applications looking for recurrence or persistence of disease in women with a demonstrated history of gestational trophoblastic disease.