tumor category was expanded by the addition of epithelioid trophoblastic
tumor and cystic trophoblastic
neoplasia-pathogenesis and potential therapeutic targets.
Because the subsequent prolongation of thyroid function impairment could induce respiratory insufficiency and in molar pregnancy with hyperthyroidism, patients have encountered acute cardiopulmonary distress following suction evacuation under general anesthesia and massive trophoblastic
embolism, death may occur (10, 11).
There are also specific recommendations for treatment of two even rarer intermediate trophoblastic
tumor types: placental-site trophoblastic
tumor and epithelioid trophoblastic
There were several differential diagnoses, such as cesarean scar pregnancy, retention placenta accreta, and gestational trophoblastic
Keywords: Choriocarcinoma, Gestational trophoblastic
neoplasia, Molar pregnancy.
A study reported that ADAMTS-12 is abundantly expressed in invasive human trophoblastic
cells, and the decreased or abolished expression of ADAMTS-12 leads to a decrease in the invasive behavior of the trophoblastic
cells, indicating that ADAMTS-12 is critical in the regulation of trophoblast invasion (10).
Degenerative changes in the form of trophoblastic
apoptosis were found in placentas from pregnancies complicated by fetal growth restriction, resulting from hypoxia (Heazell & Crocker, 2008); Jeschke et al.
The potential diagnosis of hydatidiform mole is often made by ultrasound, but histological examination of the evacuated material is essential to confirm the diagnosis. In our case, empty uterus coexisting with high level of [sz]-HCG suggested first an ectopic pregnancy, and gestational trophoblastic
disease (GTN) was less probable.
Preoperative diagnosis of PP was confirmed as extreme trophoblastic
invasion that involved the serosa of the uterus during postoperative histopathologic evaluation.
Hydatidiform mole is the premalignant form of gestational trophoblastic
disease (GTD) is a spectrum of disorders that arise from the placental trophoblast [18, 19].