trophoblast


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trophoblast

 [trof´o-blast]
the peripheral cells of the blastocyst, which attach the zygote (fertilized ovum) to the uterine wall and become the placenta and the membranes that nourish and protect the developing organism. The inner cellular layer is the cytotrophoblast and the outer layer is the syntrophoblast.

troph·o·blast

(trof'ō-blast, trō'fō-blast),
The mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and through which the embryo receives nourishment from the mother; the cells do not enter into the formation of the embryo itself but contribute to formation of the placenta. The trophoblast develops processes that later receive a core of vascular mesoderm and are then known as the chorionic villi; the trophoblast soon becomes two layered, differentiating into the syncytiotrophoblast, an outer layer consisting of a multinucleated protoplasmic mass (syncytium), and the cytotrophoblast, the inner layer next to the mesoderm in which the cells retain their membranes.
Synonym(s): chorionic ectoderm
[tropho- + G. blastos, germ]

trophoblast

(trō′fə-blăst′)
n.
The outermost layer of cells of the mammalian blastocyst that attaches the fertilized ovum to the uterine wall and serves as a nutritive pathway for the embryo.

tro′pho·blas′tic adj.

troph·o·blast

(trō'fō-blast)
The mesectodermal cell layer covering the blastocyst, which erodes the uterine mucosa and through which the embryo receives nourishment from the mother; the cells do not enter into the formation of the embryo itself, but contribute to the formation of the placenta. The trophoblast develops processes that later receive a core of vascular mesoderm and are then known as the chorionic villi; the trophoblast soon becomes two-layered, differentiating into the syncytiotrophoblast, an outer layer consisting of a multinucleated protoplasmic mass (syncytium), and the cytotrophoblast, the inner layer next to the mesoderm in which the cells retain their membranes.
[tropho- + G. blastos, germ]

trophoblast

The outer layer of the BLASTOCYST.

trophoblast

the outermost layer of cells surrounding the BLASTOCYST, consisting of embryonic epithelium, which subsequently encloses all the embryonic structures of the developing mammal and forms the outer layer of the CHORION and the embryonic side of the placenta.

Trophoblast

The tissues that surround an embryo and attach it to the uterus.
Mentioned in: Choriocarcinoma

troph·o·blast

(trō'fō-blast)
Mesectodermal cell layer covering the blastocyst that erodes uterine mucosa and through which embryo receives nourishment from mother.
[tropho- + G. blastos, germ]
References in periodicals archive ?
Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.
Using this approach, our study demonstrated, to our knowledge for the first time, that MEHP affects villous trophoblast differentiation.
Extrauterine lesions of intermediate trophoblast. Int J Gynecol Pathol.
The lack of placental development can directly bring about congenital defects, and villous lesions such as trophoblastic necrosis, edema, immaturity, thrombosis, and trophoblast inclusions are also found more frequently in neural tube defects and chromosomal disorders (Castejon & Molinaro).
Placentation requires release of special MMPs, trophoblast invasion, and spiral arteries remodeling, as well as the eventual embodiment of ECM structure (3).
CCL17 Induces Trophoblast Migration and Invasion by Regulating Matrix Metalloproteinase and Integrin Expression in Human First-Trimester Placenta.
For the RAS siRNA studies, transfection of trophoblast cells was performed as previously described [35] using K-Ras siRNA (siKRAS), H-Ras siRNA (siHRAS), and negative control siRNA (siCONT) obtained from Ambion (Thermo Fisher Scientific; Scoresby, Vic, Australia).
Galectin-9 (Gal-9), a member of the [beta]-galactoside-binding lectin family, is expressed in the epithelium of the gastrointestinal tract, trophoblast cells, and several types of immune cells [12-14].
We can therefore say that the shedding of trophoblast debris from the placenta could lead to the downregulation of the NKG2D receptor [26].
Trophoblast cells, mesenchymal cells, and endothelial cells of vessels are the main cell types of the placenta.
In physiological conditions, the invasion of the extravillous trophoblast involves the integrin heterodimers which recognize the laminin/collagen IV and fibronectin in the decidual extracellular matrix (ECM) [5].
The primary human trophoblast cells of full-term placentae have been shown to be refractory to historic strains of Zika virus from Uganda (MR766) and Cambodia (FSS13025).