troleandomycin


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troleandomycin

 [tro″le-an-do-mi´sin]
a macrolide antibiotic used in treatment of pneumonia and streptococcal infections.

troleandomycin

/tro·le·an·do·my·cin/ (tro″le-an-do-mi´sin) a macrolide antibiotic used in the treatment of pneumococcal pneumonia and Group A infections.

troleandomycin

[trol′ē·an′dōmī′sin]
a macrolide antibiotic.
indications It is prescribed in the treatment of certain infections, including pneumococcal pneumonia and group A streptococcal infections of the upper respiratory tract. It has orphan drug status for the treatment of corticosteroid-dependent asthma due to its steroid-sparing properties.
contraindications Known hypersensitivity to this drug or concomitant use of ergot alkaloids prohibits its use.
adverse effects Among the more serious adverse effects are GI disturbances, mild to severe allergic reactions (including anaphylaxis), and hepatotoxicity.

troleandomycin

the triacetyl ester of oleandomycin; a macrolide antibiotic, similar to erythromycin. Called also triacetyloleandomycin.
References in periodicals archive ?
Avoid administration with ketoconazole, itraconazole, ritonavir, erythromycin and troleandomycin.
Relpax should not be used within at least 72 hours of treatment with the following potent CYP3A4 inhibitors: ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir.
It should not be used within at least 72 hours of treatment with ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir.
Of particular interest for dangerous interactions are enoxacin, fluvoxamine, mexiletine, propanolol, and troleandomycin.
The concomitant use of fentanyl transdermal system with all cytochrome P450 3A4 inhibitors (such as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, nefazodone, amiodarone, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, and verapamil) may result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression.
Drug Reference Erythromycin and troleandomycin [112] Cyclosporine [113] FK506 [114] Lidocaine [115] Nifedipine [116] Tamoxifen [117] Others [118]
5 mEq/L at initiation; creatinine clearance less than or equal to 30 mL/min; concomitant use with the following potent CYP3A4 inhibitors: ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir, or other drugs described in their labeling as strong inhibitors of CYP3A4.
Relpax should not be used within at least 72 hours of treatment with the following potent CYP3A4 inhibitors: ketoconazole, itraconazole, nefazondone, troleandomycin, clarithromycin, ritonavir, and nelfinavir.
Potent inhibitors of cytochrome P450 3A4 and 2C9 have not been studied clinically but in vitro studies show significant inhibition of the formation of the active metabolite by inhibitors of P450 3A4 (ketoconazole, troleandomycin, gestodene), or P450 2C9 (sulfaphenazole) and nearly complete inhibition by the combination of sulfaphenazole and ketoconazole.
WARNING: YOU MUST NOT TAKE SELDANE(R) (terfenadine) if you are also taking the prescription antifungal medicines itraconazole (Sporanox(R)) or ketoconazole (Nizoral(R)) or the prescription antibiotics erythromycin, clarithromycin (Biaxin(R)), or troleandomycin (TAO(R)), or if you have liver disease.
A) WARNING: YOU MUST NOT TAKE SELDANE-D(R) (terfenadine 60mg and pseudoephedrine HCl 120 mg OR SELDANE(R) (terfenadine) if you are also taking the prescription antifungal medicines intraconazole (Sporanox(R)) or ketoconazole (Nizoral(R)) or the prescription antibiotics erythromycin, clarithromycin (Biaxin(R)), or troleandomycin (TA0(R)), or if you have liver disease.