(Rezulin) Professional Product Labeling, in PHYSICIANS' DESK REFERENCE 2118 (52d ed.
, marketed by Glaxo Wellcome in the United Kingdom, was withdrawn from the market in Europe for an extended period.
(Rezulin[R]) is an FDA-approved drug which increases insulin-dependent glucose utilization and reduces hepatic glucose output.
New research has offered hope that troglitazone
, a widely prescribed diabetes drug, could become a new colon cancer therapy, but some scientists also express concern that the drug may trigger the cancer in genetically susceptible people.
Rezulin, known chemically as troglitazone
, somehow resensitizes the body to insulin, a hormone that converts blood sugar into energy.
11 A Mechanistic View of Troglitazone
Hepatotoxicity (Rawiwan Maniratanachote and Tsuyoshi Yokoi).
The trends for 16 representative chemicals (captan, dicofol, butachlor, dimethyl terephthalate, sodium L-ascorbate, octanoic acid, chlorpyrifos-methyl, oxadiazon, pioglitazone, farglitazar, troglitazone
, thiram, fludioxonil, mercuric chloride, fluazinam, and tetramethrin) are shown in Figure 3.
, rifampin, barbiturates, carbamazepine) may increase repaglinide metabolism and thereby decrease its antidiabetic effect when used concurrently (Table 5).
20] Finally, one confounding factor that may have had an impact on the lower utilization of TZDs overall, was the concern with troglitazone
, another TZD.
In rat and human corticotroph adenoma cell series, troglitazone
and rosiglitazone decreased the tumor cell growth, increased the apoptosis and lowered the ACTH secretion by inhibiting POMC mRNA expression (16).
3], 10 nM DEX, 100 nM insulin, and 5 [micro]M troglitazone
Risks of troglitazone
apparent before approval in USA.