, LY294002 and an insulin sensitizer have been used for treatment of nutrient deprivation and have been demonstrated to kill cancer cells only under nutrient-deprivation conditions (Awale et al.
The fact that recent data shows that the exVive3D Human Liver Tissue clearly demonstrated the toxicity of another drug missed during preclinical studies, troglitazone
(Rezulin), which exhibited a clear response by causing a statistically significant drop in liver function in our liver tissue at 7 days, provides the potential for our commercial penetration to accelerate even faster.
Insulin-sensitizing drugs (metformin, troglitazone
, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovarian syndrome.
Rosiglitazone and troglitazone
are antidiabetic thiazolidinedione drugs that exert their therapeutic effects by activating peroxisome proliferator-activated receptors (PPARs).
Insulin-sensitising drugs (metformin, troglitazone
, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome.
Comparison of anti-inflammatory properties of peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone
in prophylactic treatment of experimental colitis.
There are very few studies done to report and compare the beneficial effects of troglitazone
on blood sugar in obese subjects with other oral antidiabetic drugs (67).
Regulation of lipoprotein lipase gene expression by insulin and troglitazone
in rainbow trout (Oncorhynchus mykiss) adipocyte cells in culture.
Examples are hypoglycemia and weight gain from insulin and sulfonylureas, as well as other less common but important side effects such as liver failure from troglitazone
(Rezulin, withdrawn from the market in 2000), coronary artery disease from rosiglitazone, bladder cancer from pioglitazone, pancreatitis from incretin mimetics or DPP-4 inhibitors, and lactic acidosis from metformin.
an antidiabetic drug, improves left ventricular mass and diastolic function in normotensive diabetic patients.
2] Profiler PCR Arrays in distinguishing between a diabetes drug that was discontinued due to high liver toxicity, troglitazone
(Tro), previously sold as Rezulin, and two other drugs still on the market, rosiglitazone (Rosi, sold as Avandia[R] and pioglitazone (Pio, sold as ACTOS[R]).
15- Deoxydelta12,14-PGJ2, but not troglitazone
, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways.