trisomic


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Related to trisomic: monosomic

tri·so·mic

(trī-sō'mik),
Relating to trisomy.

tri·so·mic

(trī-sō'mik)
Relating to trisomy.

trisomic

(tri-som'ik)
In genetics, an individual possessing 2n+1 chromosomes, that is, one set of chromosomes contains an extra (third) chromosome.
See: chromosome; karyotype
References in periodicals archive ?
This model is trisomic for most of the genes found on human chromosome 21.
Using the above information, researchers led by Catherine Spong at the National Institutes of Health in Bethesda, Maryland, injected NAP and SAL into mice pregnant with trisomic pups in the middle of their pregnancy.
Three DNA fragments, visualized as peaks of approximately the same height in an electropherogram, or peak ratios of 2:1 and 1:2, are indications that the sample is in the trisomic range.
In twin pregnancies where only one of the gestations is trisomic, the overabundance of the respective chromosome is still detectable as long as the effective fetal fraction is above the detection threshold.
The clinical manifestations depend on the tissues involved and the proportion of trisomic cells present.
SNP array platforms may also be used to generate signal-intensity information, thereby permitting assignment of trisomic genotypes via CNV-prediction algorithms (7).
com ) and Istvan Merchenthaler, professor, epidemiology and preventative medicine, University of Maryland, Baltimore ($143,278) : developing a therapeutic regimen called Fertamax to prevent egg aneuploidy, infertility, miscarriages, and trisomic pregnancies for women over 35.
The early biopsy material demonstrated 5% of the cells to be trisomic for chromosome 5, but the autopsy demonstrated only 1% of cells to show trisomy 5.
Posiphen[R] is distinct from the Alzheimer's drugs currently available or in clinical development, because Posiphen, a small orally active compound, has been shown in cell cultures as well as in normal, transgenic (model of Alzheimer's disease) and trisomic (model of Down Syndrome) mice to reduce the synthesis of APP which is cleaved into a number of toxic peptides, including amyloid-42 (A42).
Kimberly Bjugstad, Instructor, Psychiatry, UCHSC -- Neural Stem Cells as Potential for Down Syndrome Using Young and Aged Trisomic Ts65Dn Mice ($100K) 3.
Posiphen, a small orally active compound, has been shown in cell cultures as well as in normal, transgenic (model of AD) and trisomic (model of DS) mice to reduce the synthesis of APP which is cleaved into a number of toxic peptides, including amyloid-42 (A42).