To this aim, a bioinformatic analysis of Hsa21 miRNA target prediction by different databases was performed and cross-validated using the gene expression profiling dataset we previously generated for trisomic
These results indicated that the assay was sensitive to TACS GC-content differences, and enabled us to construct an optimal set of TACS on chromosomes 21, 18, and 13 that resulted in the correct classification of all normal and trisomic
This model is trisomic
for most of the genes found on human chromosome 21.
The ability to detect a small increase in the amount of an individual chromosome in a pregnancy, thereby determining whether it is trisomic
or disomic, depends on the proportion of fetal cfDNA that is present in maternal plasma, compared with maternal cfDNA.
The same appears to hold for Ts65Dn mice, the partial trisomic
model generated by Sago et al.
The scientists found that inhibition of neurotransmitter GABA in trisomic
mice can improve cognition and this could eventually be used in children.
Indeed, a recent study provided the evidence that trisomy for the DSCR is necessary but not sufficient for the brain phenotypes observed in trisomic
mice (Olson et al., 2007).
Balanced tertiary trisomic
for use in hybrid seed production.
-- Chromosomal abnormalities accounted for more than half of 1,103 miscarriages karyotyped in a recent study, and the majority of abnormalities in women aged over 40 years were trisomic
oocytes and a less efficient uterus have been identified as independent risks for older women (21).
Maternal age effect: the enigma of Down syndrome and other trisomic
If a trisomic
individual is conceived, and if the trisomy is viable, the child may be born with a disorder such as Down's syndrome.