This model is trisomic
for most of the genes found on human chromosome 21.
Using the above information, researchers led by Catherine Spong at the National Institutes of Health in Bethesda, Maryland, injected NAP and SAL into mice pregnant with trisomic
pups in the middle of their pregnancy.
Three DNA fragments, visualized as peaks of approximately the same height in an electropherogram, or peak ratios of 2:1 and 1:2, are indications that the sample is in the trisomic
In twin pregnancies where only one of the gestations is trisomic
, the overabundance of the respective chromosome is still detectable as long as the effective fetal fraction is above the detection threshold.
The clinical manifestations depend on the tissues involved and the proportion of trisomic
SNP array platforms may also be used to generate signal-intensity information, thereby permitting assignment of trisomic
genotypes via CNV-prediction algorithms (7).
com ) and Istvan Merchenthaler, professor, epidemiology and preventative medicine, University of Maryland, Baltimore ($143,278) : developing a therapeutic regimen called Fertamax to prevent egg aneuploidy, infertility, miscarriages, and trisomic
pregnancies for women over 35.
The early biopsy material demonstrated 5% of the cells to be trisomic
for chromosome 5, but the autopsy demonstrated only 1% of cells to show trisomy 5.
Posiphen[R] is distinct from the Alzheimer's drugs currently available or in clinical development, because Posiphen, a small orally active compound, has been shown in cell cultures as well as in normal, transgenic (model of Alzheimer's disease) and trisomic
(model of Down Syndrome) mice to reduce the synthesis of APP which is cleaved into a number of toxic peptides, including amyloid-42 (A42).
This approach has been shown to be highly robust in distinguishing trisomic
and euploid cases.
Kimberly Bjugstad, Instructor, Psychiatry, UCHSC -- Neural Stem Cells as Potential for Down Syndrome Using Young and Aged Trisomic
Ts65Dn Mice ($100K) 3.
Posiphen, a small orally active compound, has been shown in cell cultures as well as in normal, transgenic (model of AD) and trisomic
(model of DS) mice to reduce the synthesis of APP which is cleaved into a number of toxic peptides, including amyloid-42 (A42).