Treatment was started from Day 21 of the first menstrual cycle with a 0.012 mg/kg injection of triptorelin
(Diphereline, Ipsen, France).
M2 PHARMA-June 14, 2019-Debiopharm and Ipsen Extend Their Strategic Decapeptyl (triptorelin
)Partnership for Another 15 Years
In the routine protocol of the clinic of paediatric endocrinology outpatient; for the treatment of PP, GnRHa leuprolide (Lucrin 3.75 mg depot) or triptorelin
(Decapeptyl 3.75 mg depot) is intramuscularly administered every 28 days with a dose of 3.75 mg if the patient has a weight >20 kg and with a dose of 1.875 mg if the patient has a weight <20 kg (2).
Prospective, randomized, controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LH-RH) antagonist (cetrorelix) or a depot formula of an LH-RH agonist (triptorelin
The main GnRH analogs commercially used for ovulation induction in pigs are triptorelin
and buserelin, and the differences between the two are mainly related to route and time of administration according to the protocol of synchronization (KNOX et al., 2011; DRIANCOURT et al., 2013; KIRKWOOD & KAUFFOLD, 2015).
Objective: To investigate the effects of laparoscopic surgery combined with triptorelin
acetate, gestrinone and mifepristone on pregnancy rate, pregnancy outcome, long-term recurrence and adverse reactions in patients with endometriosis (EMT) complicated with infertility.
As a result of this decision, further development of generic long-acting injectables beyond Spherotide (generic long-acting triptorelin
) will only be pursued if additional resources become available.
LHRH analogs include; leuprolide (Lupron, Eligard), goserelin (Zoladex), triptorelin
(Trelstar), and histrelin (Vantas).
Prevention of Menopause Induced by Chemotherapy (PROMISE) (21) isimli randomize kontrollu calismada kemoterapi sirasinda Triptorelin
ve Goserelin kullaniminin ovaryan yetmezlik gelisimini anlamli sekilde azalttigi gozlenmistir (21).
Single-centre Bicalutamide 50 mg daily 153 during the first 4 weeks L, LA, & met Kawakami LHRH(a) (goserelin, leuprolide, 2013 (11) or buserelin) Single-centre 69 Met Dason 2013 (10) LHRH(a) (goserelin, leuprolide, Cohort series or triptorelin
), 3-month depots 32 and a 1-month course of L, LA, & met bicalutamide on ADT initiation OR LHRH antagonist (degarelix), 1-month depots Study type/n/ T level setting Klotz [less than or equal to]0.7 nmol/l 2015 (8) RCT, (NT year 1; Multicentre n=489) 626 >0.7 to <1.7 Recurrent nmol/l (NT year 1; n=129) [greater than or equal to]1.7 nmol/l (NT year 1; n=8) Wang 2016 (12) [less than or equal to]0.9 nmol/l Single-centre (n=98) 206 Met >0.9 nmol/l (n=108) Bertaglia <0.7 nmol/l 2013 (9) (n=25)vs.
we determine that Petitioner has shown by a preponderance of the evidence that all claims of the '438 patent for which trial was instituted, namely, claims 1-20, are unpatentable." The '438 patent describes administration of a therapeutically effective amount of a CYP17 inhibitor, such as abiraterone acetate, with a therapeutically effective amount of at least one additional therapeutic agent including, but not limited to, an anti-cancer agent, such as mitoxantrone, paclitaxel, docetaxel, leuprolide, goserelin, triptorelin
, seocalcitol, bicalutamide, or flutamide, or a steroid, such as hydrocortisone, prednisone, or dexamethasone, the ruling states.
Also in humans, a clinical combination of melatonin and the LHRH analogue triptorelin
was tested in metastatic prostate cancer patients with promising results.