triptans


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triptans

A group of drugs, known as selective serotonin agonists, with effects similar to those of the neurotransmitter SEROTONIN. Their action is uncertain, but they are thought to act by tightening the branches of the carotid arteries that supply the scalp and brain. They may also act on the main sensory nerve of the face and head. They are effective in controlling the symptoms of MIGRAINE, especially if supplemented by the gastrokinetic drug trimebutine. The group includes almotriptan (Almogran), frovatriptan (Migard), naratriptan (Naramig), rizatriptan (Maxalt), sumatriptan (Imigran), zolmitriptan (Zomig).
References in periodicals archive ?
The "Global Migraine Drugs Market (By Drugs - Triptan, CGRP, Acetylcholine Inhibitors/ Neurotoxins & Others; Nations-The US, the UK, Germany, France, Italy, Spain and Japan) - Outlook 2025" report has been added to ResearchAndMarkets.com's offering.
Triptans have been used for decades, but they don't help everyone, Lipton said.
Overall, the investigators found 19,017 patients who were prescribed both triptans and an SSRI or SNRI.
To assess the effect of prior triptan exposure on lasmiditan efficacy, a post-hoc analysis of the pooled Phase 3 studies was conducted on patients who reported taking triptans within three months of trial enrollment.
More than half of respondents reported complete or very effective treatment for triptans (54%) and oxygen (also 54%).
Importantly, although triptans all have a similar mechanism of action, patients might respond differently to different drugs within the class.
The presence of allodynia is important because it is found to be correlated with unresponsiveness to triptans and chronification of migraine.
The drug doesn't cause the vasoconstrictive effects that make triptans, which target 5-HT IB/ID receptors, contraindicated in patients with cardiovascular disease.
Food and Drug Administration issued an advisory warning on the risk of serotonin syndrome with concomitant use of triptans and SSRI or SNRI antidepressants, Yulia Orlova, M.D., Ph.D., from Brigham and Women's Hospital in Boston, and colleagues used electronic health record data to examine the risk of serotonin syndrome.
Triptans were developed to constrict blood vessels and so relieve pain.
The most common prescription medication used for migraine headache abortion are the 5-HTIB/1D receptor agonists, better known as the "triptans" (Goadsby & Raskin, 2012).
Acute migraine treatment market is dominant by Triptans and most of them are available as pills.