triple therapy

AIDS Any 3-agent antiretroviral regimen—in developing nations, D4T, 3TC and nevirapine—to manage HIV-1 infection; in general, the use of multiple agents of different classes is thought to improve the probability of a positive outcome
Cardiology
(1) The use of 3 agents—e.g., ARBs, beta blockers and ACE inhibitors—to decrease morbidity and mortality in patients with congestive heart failure
(2) Triple antithrombotic therapy The simultaneous use of aspirin, clopidogrel and warfarin. No clots, copious bleeding
Fringe medicine A combination of herbs, yoga, meditation and diet to manage HIV-1+ patients
Gastroenterology A therapy that requires 3 modalities or agents—e.g., TT for H pylori infection includes a proton-pump inhibitor (e.g., omeprazole) and 2 antibiotics (e.g., amoxicillin, clarithromycin)
Hepatology A combination of Zadaxin®, pegylated IFN alpha and ribavirin, used to manage HPV C in nonresponders to IFN and ribavirin alone
Obstetrics The administration of low-dose aspirin, heparin, and prednisone in a habitual aborter with primary antiphospholipid syndrome at an increased risk of DVTs Note: Corticosteroids are ineffective in APS and increase maternal morbidity and foetal prematurity
Oncology—lung The use of 3 different chemotherapeutics—e.g., vinorelbine, gemcitabine, and carboplatin—in patients with non-small cell CA of lung
Oncology—lymphoma Alternating triple therapy The alternating of 3 different chemotherapy regimens—e.g., CHOP-MINE-ESHAP in lymphoma
Oncology—pancreas The use of 3 chemotherapeutics—e.g., gemcitabine, cisplatin, infused fluorouracil—in pancreatic cancer
Pulmonary medicine The use of 3 agents—inhaled corticosteroids, long-acting 2-agonists (e.g., salmeterol) and leukotriene modifiers (e.g., montelukast). Leukotrienes do not help in asthma
Transplantation A 3-agent immunosuppressant regimen—e.g., cyclosporine, azathioprine (or everolimus), and methylprednisolone—to minimize rejection in patients receiving lungs or other transplanted organs See Asthma
Urology The use of hormonal therapy, brachytherapy, and external beam radiation for local control in high-risk prostates See Prostate CA

triple therapy

Infectious disease The use of 3 antibiotics–ampicillin, gentamicin, metronidazole-to 'cover' for acute diverticulitis. See Acute diverticulitis Medtalk A therapy that requires 3 modalities/agents–eg, TT for H pylori includes a proton-pump inhibitor–eg, omeprazole and 2 antibiotics–eg, amoxicillin, clarithromycin.
References in periodicals archive ?
This effect is exemplified in the United Kingdom, where 45 percent of non-cirrhotic treatment-naive genotype-1 patients were being treated with IFN dual therapy or first generation protease inhibitor triple therapy, according to survey results, though this will change rapidly with the recent approval of new direct acting antivirals in the UK in late 2015.
Specifically, researchers will compare sulfasalazine (SSZ) plus hydroxychloroquine plus methotrexate (MTX), commonly referred to as triple therapy, to MTX in combination with a Tumor Necrosis Factor (TNF) inhibitor.
The cost of the drugs in advanced nations can reach thousands of dollars a year, but the cost to underdeveloped nations can be relatively low when purchased from India in generic form " less than $100 a year for the triple therapy and somewhat less for Truvada.
Clarithromycin, metronidazole, and levofloxacin resistances were all high among untreated patients, suggesting that they all should be avoided as components of empiric triple therapy [consisting of a] proton pump inhibitor, amoxicillin, plus a third antibiotic," said the researchers.
The results of the present study demonstrate that the addition of a low-nickel diet to standard triple therapy significantly increased the H.
Rather than supplementing high dose of Vit C along with conventional triple therapy, it is preferable to complete the conventional therapy and thereafter start Vit C supplementation for extended period which would prevent reinfection in susceptible individuals, provided the patients are not achlorhydric.
The researchers divided study time into two blocks: 1993-1995 (before use of triple antiretroviral therapy) and 1996-2007 (when triple therapy was available).
We used the following search terms: rheumatoid arthritis, randomized trial, MTX, DMARDs, triple therapy rheumatoid, and combination therapy to retrieve clinical trials, including combination therapy of MTX with other DMARDs.
In addition, there are ongoing discussions among the liver experts about triple therapy rather than dual therapy.
Among patients with an undetectable hepatitis C virus level at treatment week 8, the rate of sustained virologic response was 86 percent after 32 weeks of triple therapy and 88 percent after 44 weeks of triple therapy.
This study displays the ability to eradicate the bacteria, but not to the same extent as allopathic triple therapy.