triple therapy

AIDS Any 3-agent antiretroviral regimen—in developing nations, D4T, 3TC and nevirapine—to manage HIV-1 infection; in general, the use of multiple agents of different classes is thought to improve the probability of a positive outcome
Cardiology
(1) The use of 3 agents—e.g., ARBs, beta blockers and ACE inhibitors—to decrease morbidity and mortality in patients with congestive heart failure
(2) Triple antithrombotic therapy The simultaneous use of aspirin, clopidogrel and warfarin. No clots, copious bleeding
Fringe medicine A combination of herbs, yoga, meditation and diet to manage HIV-1+ patients
Gastroenterology A therapy that requires 3 modalities or agents—e.g., TT for H pylori infection includes a proton-pump inhibitor (e.g., omeprazole) and 2 antibiotics (e.g., amoxicillin, clarithromycin)
Hepatology A combination of Zadaxin®, pegylated IFN alpha and ribavirin, used to manage HPV C in nonresponders to IFN and ribavirin alone
Obstetrics The administration of low-dose aspirin, heparin, and prednisone in a habitual aborter with primary antiphospholipid syndrome at an increased risk of DVTs Note: Corticosteroids are ineffective in APS and increase maternal morbidity and foetal prematurity
Oncology—lung The use of 3 different chemotherapeutics—e.g., vinorelbine, gemcitabine, and carboplatin—in patients with non-small cell CA of lung
Oncology—lymphoma Alternating triple therapy The alternating of 3 different chemotherapy regimens—e.g., CHOP-MINE-ESHAP in lymphoma
Oncology—pancreas The use of 3 chemotherapeutics—e.g., gemcitabine, cisplatin, infused fluorouracil—in pancreatic cancer
Pulmonary medicine The use of 3 agents—inhaled corticosteroids, long-acting 2-agonists (e.g., salmeterol) and leukotriene modifiers (e.g., montelukast). Leukotrienes do not help in asthma
Transplantation A 3-agent immunosuppressant regimen—e.g., cyclosporine, azathioprine (or everolimus), and methylprednisolone—to minimize rejection in patients receiving lungs or other transplanted organs See Asthma
Urology The use of hormonal therapy, brachytherapy, and external beam radiation for local control in high-risk prostates See Prostate CA

triple therapy

Infectious disease The use of 3 antibiotics–ampicillin, gentamicin, metronidazole-to 'cover' for acute diverticulitis. See Acute diverticulitis Medtalk A therapy that requires 3 modalities/agents–eg, TT for H pylori includes a proton-pump inhibitor–eg, omeprazole and 2 antibiotics–eg, amoxicillin, clarithromycin.
References in periodicals archive ?
Because the effect of CsA-based triple therapy may already be detectable at basal concentrations of whole blood TNF-[alpha] mRNA, the effect on monocyte function and, potentially, TNF-[alpha] could also be relevant for immunosuppressive drug monitoring.
The cheapest triple therapy treatment for HIV/AIDS has fallen to around $30 a month, from about $40 a year ago and $600 three years ago, although even $30 is still not affordable to a majority of Ugandans.
Hydrogels having excellent swelling properties at the acidic medium could be a good candidate for this dual therapy with site specificity, high sensitivity, and safety without the side effects of the triple therapy. Hydrogels prepared from chitosan and poly vinylpyrrolidone were incorporated with Ciprofloxacin and Roxatidine and drug release pattern were studied.
One Kenyan manufacturer that has already been working for 1 1/2 years to produce triple therapy drugs will have to wait at least six months for their drugs to be licensed, BBC Online reported, adding that the country's health service is "ramshackle" (Ishbel Matheson, BBC Online, May 1).
Although rhubarb galloyl-tannin worked best in this study when given before the animals were exposed to cholera toxin, Noda says he thinks it could help people with cholera as part of a "triple therapy," with antibiotics and oral rehydration.
One week of triple therapy combining omeprazole, amoxicillin, and clarithromycin results in successful eradication of Helicobacter pylori in nearly 75% of children with gastritis.
"One major reason that only Brazil offers free triple therapy is that, until now, there was no Brazil to show that it is possible," reported The New York Times Magazine.
With prices currently announced for poor countries by other pharmaceutical companies (which might be reduced in the near future), prices to Africans for triple therapy including either Crixivan or Stochrin (efavirenz) will still be over $1000 per person per year.
In fact, the journal AIDS[16] just published an analysis by the British Columbia Centre for Excellence in HIV/AIDS challenging the notion that a PI-based regimen or triple therapy "per se alters the natural history of HIV infection with respect to the relationship between pVL [plasma viral load] and CD4 cell count." After analyzing the results from 3 multinational clinical trials (INCAS, AVANTI-2 and AVANTI-3) they conclude, "The relationship between changes in CD4 cell count and pVL are independent of the specific antiretroviral therapy used, including the potency of the regimen or the drug class(es) included in it.
Adults are treated with "triple therapy" - bismuth subsalicylate (Pepto-Bismol), metronidazole and amoxicillin.
The most effective therapy, according to the NIH Panel, is a 2-week, triple therapy. This regimen eradicates the bacteria and reduces the risk of ulcer recurrence in 90 percent of people with duodenal ulcers.
pylori detected by histology were treated with triple therapy consisting of amoxycillin 500 mg TDS, metronidazole 400 mg TDS for 14 days and de-Noltab (tripotassium dicitratobismuthate 20 mg) two tablets bd for 28 days.