The tricyclic trimipramine
in the treatment of subjective tinnitus.
Effects of polymorphisms in CYP2D6, CYP2C9, and CYP2C19 on trimipramine
The non-SSRIs used were amitriptyline, clomipramine, imipramine, lofepramine, nortriptyline, maprotiline, mianserin, moclobemide, trimipramine
, and venlaflaxine.
B depressants No more effective than (6) (trimipramine
, placebo at relieving gloal desipramine) IBS symptoms (3.2-5) (23,24,36-39) Loperamide Relieves diarrhea.
TCAs studied included amitriptyline, imipramine, clomipramine, doxepin, dothiepin, trimipramine
, and lofepramine.
Selected psychotropics that affect P-glycoprotein Substrates Amitriptyline Paroxetine Carbamazepine Quetiapine Chlorpromazine Risperidone Citalopram Sertraline Doxepin Topiramate Nortriptyline Venlafaxine Olanzapine Inhibitors Amitriptyline Imipramine Carbamazepine Nefazodone Chforpromazine Paroxetine Desipramine Sertraline Disulfiram Thioridazine Fluoxetine Trifluoperazine Fluvoxamine Trimipramine
Haloperidol Inducers(a) Amitriptyline Phenothiazines Nefazodone Trazodone (a.) Data supporting induction is limited Source: Reference 8 Gary M.
Olanzapine was extracted from 1 mL of serum after the addition of 0.2 mL of bicarbonate buffer (pH 10.5), 20 [micro]L of internal standard working solution (demethylated metabolite of trimipramine
; 2 mg/L), and 5 mL of a mixture of hexane-isoamyl alcohol (98:2 by volume).
Of the 11 placebo-controlled studies of irritable bowel syndrome or functional dyspepsia, 10 studied TCAs (trimipramine
,[87-89] desipramine,[85,86] amitriptyline,[84,90,91] doxepin, and clomipramine) and 2 studied mianserin.[94,95] All showed benefit for at least one of the following outcomes: functional status,[86,95] stool frequency, symptom scores,[84,87,88] pain[85,90,94,95] and rectosigmoid contractions. Thus, every study except one of an antidepressant for irritable bowel syndrome or functional dyspepsia showed some improvement associated with the antidepressant.
Table 1 Psychotropics associated with constipation Class Medications Atypical antipsychotics Clozapine, risperidone Typical antipsychotics Chlorpromazine, haloperidol, pimozide, thioridazine, thiothixene, trifluoperazine Anticholinergics Benztropine, trihexyphenidyl Antidepressants Amitriptyline, clomipramine, doxepin, imipramine, nortriptyline, trimipramine
The underlying mechanism of clozapine-induced constipation has been well established.
trazodone Dermatitis, pruritus Amitriptyline, doxepin, trimipramine
Diarrhea, IBS Amitriptyline, doxepin, paroxetine,
Of all the drugs tested, only trimipramine
coadministration could modify the results, since its metabolite, the desmethyltrimipramine, has the same tR as the IS (18.33 min).
The TCAs identified in the 1985 NAMCS included amitriptyline, amoxapine, desipramine, doxepin, imipramine, nortriptyline, protryptiline, trimipramine
, and a combination of amitriptyline and perphenazine.