trimetrexate glucuronate

trimetrexate glucuronate

NeuTrexin® An antimetabolic lipophilic dihydrofolate reductase inhibitor–ie, antifolate structurally related to MTX, which is antineoplastic and antimicrobial; TG is approved for treating PCP when Bactrim/Septra cannot be used in immunocompromised Pts, and in Pts with colorectal, gastric, and pancreatic CA, acute leukemia, osteosarcoma; it may enhance 5-FU effectiveness in 5-FU and leucovorin-based therapy, improving survival. See Pneumocystis carinii pneumonia.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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* Trimetrexate glucuronate (with Leucovorin)(Neutrexin, TMTX), U.S.
NuTrexin (trimetrexate glucuronate) was developed by U.S.