trimetrexate


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trimetrexate

 [tri″-mĕ-trek´sāt]
a folic acid antagonist structurally related to methotrexate, used as the glucuronate salt, in combination with leucovorin, to treat Pneumocystis carinii pneumonia in acquired immunodeficiency syndrome, administered intravenously.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

trimetrexate

An inhibitor of the enzyme DIHYDROFOLATE REDUCTASE. It is used to treat Pneumocystis carinii pneumonia in people with AIDS. A brand name is Neutrexin.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Quinoxaline 10-oxa-analogues of trimetrexate (TMQ) and of 5,8-dideazafolic acid.
Paglietti, "Pirrolo[1,2-, a]quinoxalines analogues of antifolic trimetrexate and methotrexate," in Proceedings of the 16th International Symposium on Medicinal Chemistry, p.
* Federal officials announced last week that the anti-cancer drug trimetrexate has been approved for limited use in treating Pneumocystis carinii pneumonia, a serious infection often associated with AIDS.
(c) A, atovaquone; CO, cotrimoxazole; C/P, clindamycin/primaquine; D, dapsone; D+T, dapsone and trimethoprim; P, pentamidine; P+A, pentamidine and atovaquone; PM/SD (pyrimethamine/sulfadoxine inhibitors of dihydrofolate reductase (DHFR) and DHPS, respectively); T, trimetrexate (an inhibitor of DHFR).