trimetrexate


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trimetrexate

 [tri″-mĕ-trek´sāt]
a folic acid antagonist structurally related to methotrexate, used as the glucuronate salt, in combination with leucovorin, to treat Pneumocystis carinii pneumonia in acquired immunodeficiency syndrome, administered intravenously.

trimetrexate

/tri·me·trex·ate/ (tri″-mĕ-trek´sāt) a folic acid antagonist structurally related to methotrexate, used as the glucuronate salt, in combination with leukovorin, to treat pneumonia in AIDS.

trimetrexate

An inhibitor of the enzyme DIHYDROFOLATE REDUCTASE. It is used to treat Pneumocystis carinii pneumonia in people with AIDS. A brand name is Neutrexin.

trimetrexate

an antifolate and an antineoplastic agent, similar to methotrexate. Also used in the treatment of toxoplasmosis and Pneumocystis infections.
References in periodicals archive ?
c) A, atovaquone; CO, cotrimoxazole; C/P, clindamycin/primaquine; D, dapsone; D+T, dapsone and trimethoprim; P, pentamidine; P+A, pentamidine and atovaquone; PM/SD (pyrimethamine/sulfadoxine inhibitors of dihydrofolate reductase (DHFR) and DHPS, respectively); T, trimetrexate (an inhibitor of DHFR).
Current treatment options for PCP include trimethoprim-sulfamethoxazole, primaquine plus clindamycin, trimetrexate (with or without dapsone) plus leucovirin, atovaquone and pentamidine.