Quinoxaline 10-oxa-analogues of trimetrexate (TMQ) and of 5,8-dideazafolic acid.
Paglietti, "Pirrolo[1,2-, a]quinoxalines analogues of antifolic trimetrexate and methotrexate," in Proceedings of the 16th International Symposium on Medicinal Chemistry, p.
* Federal officials announced last week that the anti-cancer drug trimetrexate
has been approved for limited use in treating Pneumocystis carinii pneumonia, a serious infection often associated with AIDS.
(c) A, atovaquone; CO, cotrimoxazole; C/P, clindamycin/primaquine; D, dapsone; D+T, dapsone and trimethoprim; P, pentamidine; P+A, pentamidine and atovaquone; PM/SD (pyrimethamine/sulfadoxine inhibitors of dihydrofolate reductase (DHFR) and DHPS, respectively); T, trimetrexate
(an inhibitor of DHFR).