trimethylaminuria


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tri·meth·yl·am·i·nu·ri·a

(trī-meth'il-am'i-nyūr'ē-ă),
Increased excretion of trimethamine in urine, sweat, and saliva, with characteristically offensive fishy body odor or breath.
Synonym(s): fish-odor syndrome
A rare autosomal recessive condition [MIM 136131] characterised by an accumulation of trimethylamine (CH33N), which is released in the person’s sweat, urine, and breath, giving off a strong body odour, which often has a fishy smell
Management Choline, lecithin-free diet

tri·meth·yl·am·i·nu·ri·a

(trī-meth'il-am-i-nyūr'ē-ă)
Increased excretion of trimethylamine in urine and sweat, with a characteristic offensive, fishy body odor.
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References in periodicals archive ?
Admittedly, the non-TV critics among you might disagree, claiming there are PLENTY of less favourable situations to find oneself in - being trapped in a hot car alongside someone with trimethylaminuria (fish odour syndrome), for example.
pylori) infection], menstruation, gastroesophageal reflux disease, Trimethylaminuria, hypermethioninemia, agranulocytosis.
In a study based on the own accounts of sample individuals, it has been reported that trimethylaminuria caused by FMO3 enzyme deficiency is observed more in woman individuals.
These therapeutic agents were proposed as a treatment for patients suffering from trimethylaminuria. The patients hold a genetic disposition that prevents oxidation of TMA to trimethylamine oxide (TMAO) in the human liver.
Additionally, it was reported that a mild symptom of trimethylaminuria (TMAU) could be triggered by a TMA challenge test in patients who were homozygous with FMO3 Lys158/Gly308 [14].
[sup][58] However, individuals without functional FMO3 often exhibit a fishy odor, which is caused by trimethylaminuria. [sup][59] Taken together, these findings indicated that the suppression of FMO3 may represent a potential therapeutic target, a hypothesis that warrants additional basic and clinical research to determine the effects of silencing FMO3 and to weigh the pros and cons of this approach.
Also known as Trimethylaminuria, this unusual metabolic condition means you struggle to digest certain foods, resulting in your sweat, breath and urine giving off a pungent fishy aroma.
Shy Khan sympathised: "What happens if the person has Trimethylaminuria? Some people have that body odour problem, did the library officials think about that and how those people would feel?" Sophie O'Hagan said: "It's a disgrace, there are many homeless people sleeping rough whilst we are all sat in our warm houses.
Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients.
Today Ellie, 44, bravely reveals how she is just one of a handful of Brits to be diagnosed with Trimethylaminuria (TMAU).
The site even quoted a fake chief surgeon at St Luke's Medical Center in Colorado capital Denver saying victims, including college students, had witnessed cardiac arrests, hypospadias, acquired trimethylaminuria and multiple organ failures.