trimethoprim-sulfamethoxazole


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Related to trimethoprim-sulfamethoxazole: nitrofurantoin, ciprofloxacin, Bactrim

tri·meth·o·prim-sul·fa·meth·ox·a·zole

(trī-meth'ō-prim sŭl'fă-meth-oks'ă-zōl),
A drug combination consisting of a dihydrofolate reductase inhibitor (trimethoprim) and a sulfonamide antibacterial drug (sulfamethoxazole). The drug combination is synergistic as the drugs interfere with two successive steps in the formation/utilization of folic acid by microorganisms. Used to treat many infectious diseases.

trimethoprim-sulfamethoxazole

Bactrim®, Septra® A broad-spectrum combination antibacterial, formulated as a 1:20 ratio of T to S, which is effective in genitourinary, GI, and respiratory tract infections; it is the antibiotic of choice in PCP for which the failure rate of 5-20%; T-S is also effective against Salmonella, Shigella, Nocardia spp, H influenzae, Listeria monocytogenes, S pneumoniae, Isospora belli, and possibly Toxoplasma gondii; T-S is non-toxic in non-immunocompromised Pts; up to 60% of AIDS Pts have adverse effects–eg, ↑ LFTs, neutropenia, thrombocytopenia, erythematous maculo-papular rash, Stevens-Johnson syndrome, exfoliative dermatitis, N&V

Trimethoprim-sulfamethoxazole (TMP-SMX)

An antibiotic used to treat and prevent PCP.

tri·meth·o·prim-sul·fa·meth·ox·a·zole

(TMP/SMX) (trī-meth'ō-prim sŭl'fă-meth-oks'ă-zōl)
Drug combination consisting of a dihydrofolate reductase inhibitor and a sulfonamide antibacterial drug; drug combination is synergistic as the drugs interfere with two successive steps in formation/use of folic acid by microorganisms. Used to treat many infectious diseases.

trimethoprim-sulfamethoxazole (trīmeth´əprim´ sul´fəmethok´sə-zōl),

n a synthetic antibacterial combination effective in urinary tract infections; it is the drug of choice in the treatment of
Pneumocystis jiroveci pneumonia, one of the opportunistic infections associated with acquired immunodeficiency syndrome (AIDS).
References in periodicals archive ?
The women were given ciprofloxacin 500 mg twice daily for 7 days, followed by placebo for 7 days or trimethoprim-sulfamethoxazole 160/800 mg for 14 days.
violaceum infection is not well established; some survivors are treated with ciprofloxacin, carbapenems, chloramphenicol with aminoglycoside, or trimethoprim-sulfamethoxazole.
The patient is prescribed trimethoprim-sulfamethoxazole for 3 days along with a decongestant.
Clindamycin or trimethoprim-sulfamethoxazole is commonly used to treat mild to moderate infections.
These 6 workers were considered to be at high risk and offered a 3-week prophylactic course of combined doxycycline-rifampin or trimethoprim-sulfamethoxazole therapy.
About 25% were macrolide resistant, 9% were clindamycin resistant, 17% were tetracycline resistant, 8% were chloramphenicol resistant, and 36% were trimethoprim-sulfamethoxazole resistant.
This child had been treated with multiple antimicrobial drugs in the month before the onset of her salmonella gastroenteritis, including cephalexin, amoxicillin, trimethoprim-sulfamethoxazole, and ciprofloxacin.
Trimethoprim-sulfamethoxazole poses risks in the first trimester but not later in pregnancy.
Susceptibilities of 9 confirmed isolates to ceftazidime, chloramphenicol, colistin sulfate, gentamicin, minocycline, piperacillin/tazobactam, and trimethoprim-sulfamethoxazole were determined by using a disk diffusion method.
However, the organisms are still largely susceptible to vancomycin (Vancocin), trimethoprim-sulfamethoxazole (Septra, Bactrim), gentamicin, and clindamycin (Cleocin).
Typhimurium DTI04A variant strain in the present study was resistant to sulfonamides, tetracycline, and trimethoprim-sulfamethoxazole, which is a common resistance pattern of DT104A isolates.
Of the 178 patients treated with a regimen based on recommendations issued by the American Thoracic Society and by a Canadian panel, 105 received a second-generation cephalosporin, 59 got trimethoprim-sulfamethoxazole, 12 received amoxicillin plus clavulanate, and 2 were treated with a macrolide.