trimethoprim-sulfamethoxazole


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Related to trimethoprim-sulfamethoxazole: nitrofurantoin, ciprofloxacin, Bactrim

tri·meth·o·prim-sul·fa·meth·ox·a·zole

(trī-meth'ō-prim sŭl'fă-meth-oks'ă-zōl),
A drug combination consisting of a dihydrofolate reductase inhibitor (trimethoprim) and a sulfonamide antibacterial drug (sulfamethoxazole). The drug combination is synergistic as the drugs interfere with two successive steps in the formation/utilization of folic acid by microorganisms. Used to treat many infectious diseases.
Farlex Partner Medical Dictionary © Farlex 2012

trimethoprim-sulfamethoxazole

Bactrim®, Septra® A broad-spectrum combination antibacterial, formulated as a 1:20 ratio of T to S, which is effective in genitourinary, GI, and respiratory tract infections; it is the antibiotic of choice in PCP for which the failure rate of 5-20%; T-S is also effective against Salmonella, Shigella, Nocardia spp, H influenzae, Listeria monocytogenes, S pneumoniae, Isospora belli, and possibly Toxoplasma gondii; T-S is non-toxic in non-immunocompromised Pts; up to 60% of AIDS Pts have adverse effects–eg, ↑ LFTs, neutropenia, thrombocytopenia, erythematous maculo-papular rash, Stevens-Johnson syndrome, exfoliative dermatitis, N&V
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Trimethoprim-sulfamethoxazole (TMP-SMX)

An antibiotic used to treat and prevent PCP.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

tri·meth·o·prim-sul·fa·meth·ox·a·zole

(TMP/SMX) (trī-meth'ō-prim sŭl'fă-meth-oks'ă-zōl)
Drug combination consisting of a dihydrofolate reductase inhibitor and a sulfonamide antibacterial drug; drug combination is synergistic as the drugs interfere with two successive steps in formation/use of folic acid by microorganisms. Used to treat many infectious diseases.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Trimethoprim-sulfamethoxazole 1 600 mg/320 mg 6-hourly and prednisone 40 mg/d was started.
coli isolates were found resistant to Trimethoprim-Sulfamethoxazole, which can be compared to a study conducted in 2013.
At 1 month of follow-up, new infections were less common in the clindamycin group (6.8%) than in the trimethoprim-sulfamethoxazole group (13.5%; P = .03) or the placebo group (12.4%; P = .06).
In this analysis, 34.7% of pregnant women with UTIs in 2014 filled a prescription for nitrofurantoin and 7.6% filled a prescription for trimethoprim-sulfamethoxazole during their first trimester of pregnancy.
[18] compared the effects of trimethoprim-sulfamethoxazole treatment versus a placebo in reducing the risk of toxoplasmic retinochoroiditis recurrences.
The increasing resistance to antimicrobials like amoxicillin-clavulanate and trimethoprim-sulfamethoxazole in children is an important problem for paediatricians.
However, it is not known whether CD4+ count level, initiation of HAART, and trimethoprim-sulfamethoxazole prophylaxis, as recommended by the Ministry of Health, Community Development, Gender, Elderly and Children (MOHCDGEC) guidelines, have an impact on the prevalence of UTI, bacterial etiology, and antimicrobial resistance profiles among HIV-infected pregnant women.
It was sensitive to meropenem, imipenem, piperacillin-tazobactam, ticarcillin, trimethoprim-sulfamethoxazole, and third-generation cephalosporins.
The susceptibility report allowed her antimicrobial therapy to be transitioned to more definitive treatment consisting of high dose trimethoprim-sulfamethoxazole and IV linezolid (600 mg every 12 hours).
Doxycycline, rifampin, and either ceftriaxone or trimethoprim-sulfamethoxazole are the most commonly used treatmentregimens.
A recent study looked at whether additional community-associated MRSA coverage with trimethoprim-sulfamethoxazole in addition to beta-lactam therapy for cellulitis showed any benefit over therapy with only a beta-lactam (Clin.