trimethoprim


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trimethoprim

 [tri-meth´o-prim]
an oral antibacterial closely related to pyrimethamine, almost always administered in combination with a sulfonamide, primarily for treatment of urinary tract infections. The sulfate salt is applied topically to the conjunctiva, in combination with polymyxin B sulfate, in the treatment of ocular infections.

tri·meth·o·prim

(trī-meth'ō-prim),
An antimicrobial agent that potentiates the effect of sulfonamides and sulfones; usually used in combination with sulfamethoxazole.

trimethoprim

(trī-mĕth′ə-prĭm)
n.
An antibiotic drug, C14H18N4O3, used primarily to treat or prevent urinary tract infections, often in combination with sulfamethoxazole.

sulfamethoxazole/trimethoprim

Bactrim, see there.

tri·meth·o·prim

(TMP) (trī-meth'ō-prim)
An antimicrobial agent that potentiates the effect of sulfonamides and sulfones; usually used in combination with sulfamethoxazole (TMP/SMX).

trimethoprim

An antibacterial drug used to treat urinary and other infections. The drug is on the WHO official list. Brand names are Ipral, Monotrim and Trimopan. Combined with sulphamethoxazole it is sold as co-trimoxazole (Septrin) and Chemotrim.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.

tri·meth·o·prim

(TMP) (trī-meth'ō-prim)
An antimicrobial agent that potentiates effect of sulfonamides and sulfones.
References in periodicals archive ?
Trimethoprim sulfamethoxazole (TMP-SMX) is available in the form of tablet with the trade name as "Septra D.S" (GlaxoSmithKline Pakistan).
The identification and quantitation of sulfonamides and trimethoprim was carried out using an UPLC-Q-TOF system comprising an Acquity UPLC system coupled to a hybrid quadrupole orthogonal time-of-flight (Q-TOF) mass spectrometer (SYNAPT HDMS Q-TOF mass spectrometer) with electrospray source ionization (ESI) in positive mode.
Growths in these media with and without trimethoprim or rifampicin (0.3 [micro]g/ml) were compared on the samples of raw milk.
Serratia 1/1 1/1 2/2 4/4 3.2 liquifaciens TABLE 2 Minimum Inhibitory Concentration of Trimethoprim Against Contaminants From Lettuce Samples Trimethoprim % Inhibited Concentration (mg/L) > 1000 58 [greater than or equal to] 500 8 [greater than or equal to] 125 22 [greater than or equal to] 62.5 8 [greater than or equal to] 31.25 4 TABLE 3 Rate of Resistance Transfer Among Contaminants Recovered From Lettuce Samples Resistance Rate of Transfer (%) Streptomycin 83 Trimethoprim 70 Tetracycline 69 Chloramphenicol 0
A total of 402 children were born to 395 women exposed to a drug containing trimethoprim (trimethoprim or sulfamethoxazole plus trimethoprim) during the 12 weeks before conception (Table 1).
But the National Pharmacy Association said changing the status of trimethoprim to an over-the-counter medicine would not lead to an increase in antibiotic resistance.
Second, although the use of sulphonamides and trimethoprim decreased more than threefold during the study period, carriage of trimethoprim- and sulphonamide-resistant Gram-negative bacteria did not change.
Analysis of the GC array showed that this integron harbored 2 GCs: dfrA16 of 588 bp conferring resistance to trimethoprim and qacH of 511 bp conferring resistance to quaternary ammonium compounds (GenBank accession no.
Susceptibility to Sulphamethoxazole-Trimethoprim combination (SXT: 25 ug), Trimethoprim alone (W: 2.5 ug), Ciprofloxacin (CIP: 10 ug), Nalidixic acid (NAL: 30 ug), Cefotaxime (CTX: 30 ug), Ceftazedime (CAZ: 30 ug), Ampicillin (AMP: 25 ug) and Nitrofurantoin (F: 50 ug) was determined using standard disc diffusion method in accordance with Clinical and Laboratory Standard Institute recommendations (CLSI, 2007).
Using concealed allocation, the children were randomly assigned to a control group that did not receive antibiotic therapy or an intervention group receiving sulfamethoxazole-trimethoprim (5-10 mg/kg sulfamethoxazole plus 1-2 mg/kg trimethoprim once daily) for 2 years, after which they stopped treatment but were monitored for another 2 years.
Hartwell and Steck tested ciprofloxacin and trimethoprim, two antibiotics typically prescribed for urinary tract infections.