trimethobenzamide


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trimethobenzamide

 [tri-meth″o-ben´zah-mīd]
an antiemetic administered orally, intramuscularly, or rectally as the hydrochloride salt.

trimethobenzamide

/tri·meth·o·ben·za·mide/ (-meth″o-ben´zah-mīd) an antiemetic, used as the hydrochloride salt.

trimethobenzamide (trīmeth´ō-ben´zəmīd´),

n brand name: Arrestin, Bio-Gan, Stemetic, Ticon, Tigan, T-Gen, Triban, others;
drug class: antiemetic;
action: acts centrally by blocking the chemoreceptor trigger zone, which in turn acts on vomiting center;
uses: treatment of nausea and vomiting and prevention of postoperative vomiting.

trimethobenzamide

an ethanolamine derivative; a strong antidopaminergic antagonist which is used as a central antiemetic.
References in periodicals archive ?
Tigan and other suppository drug products that contain trimethobenzamide hydrochloride have not been shown to be effective for nausea and vomiting and should no longer be marketed, according to the Food and Drug Administration.
The FDA said patients can use alternative forms of the drug, trimethobenzamide, marketed as capsules or injections by makers including King and Icelandic generic-drug maker Actavis Group hf.
She tried dexamethasone and trimethobenzamide, and that helped to some degree.
Other common oral medications for NVP include prochlorperazine (Compazine), metoclopramide (Reglan), trimethobenzamide (Tigan), promethazine (Phenergan), and ondansetron (Zofran).
The study also looked at extrapyramidal side effects for those exposed to trimethobenzamide.
Other commonly used oral medications for NVP include prochlorperazine (Compazine), metoclopramide (Reglan), trimethobenzamide (Tigan), promethazine (Phenergan), and ondansetron (Zofran).
3 /PRNewswire/ -- United Research Laboratories and Mutual Pharmaceutical Company announced that Mutual Pharmaceutical has today received FDA approval of its Abbreviated New Drug Application (ANDA) for Trimethobenzamide 300mg capsules.
After pretreatment with trimethobenzamide, an antiemetic, they were randomized to treatment of an acute off episode using 4 mg of apomorphine or a placebo injection, then crossed over to the other study arm for treatment of another episode on a separate day.
Gregory further elaborated, "On December 24, 2002, the FDA published a Federal Register notice declaring the continued marketing of all unapproved trimethobenzamide hydrochloride capsules unlawful pursuant to our agreement with the FDA regarding King's Tigan(R) (trimethobenzamide hydrochloride) products.
King Pharmaceuticals' Tigan(R) is Sole FDA-approved Trimethobenzamide Hydrochloride Capsule in U.
Food and Drug Administration (FDA) approved the new drug application (NDA) for Tigan(R) 300mg capsules on December 13, 2001, making the product the only FDA approved trimethobenzamide hydrochloride capsule in the United States.
As a result, King now has the only FDA approved trimethobenzamide hydrochloride capsule in the United States.