This includes, but is not limited to phenothiazines, butyrophenones, hydroxyzine, lorazepam, cannabinoids, metoclopramide, corticosteroids (with the exception of topical steroids for skin disorder and inhaled steroids for respiratory disorders), trimethobenzamide
, monoamine oxidase inhibitors, lithium, and 5-HT3 receptor antagonists.
No other drugs (betahistine, difenidol, flunarizine, cinnarizine, dimenhydrinate, gingko, meclizine, metoclopramide, scopolamine, pentoxifylline, perphenazine, ergoloid mesylate, droperidol, phenobarbital, prochlorperazine, promethazine, trimethobenzamide
, or vertigoheel, etc.) or herbal drugs to manage the symptom of dizziness will not be allowed.
A Herbal Medicine, Gongjindan, in Subjects with Chronic Dizziness (GOODNESS Study): Study Protocol for a Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Clinical Trial for Effectiveness, Safety, and Cost-Effectiveness
Second, we excluded drugs that were unavailable in Taiwan, including pentazocine, trimethobenzamide
, amphetamines, guanadrel, mesoridazine, mineral oil, and desiccated thyroid.
Clinch et al., "Randomized, placebo-controlled trial of trimethobenzamide
to control nausea and vomiting during initiation and continued treatment with subcutaneous apomorphine injection," Parkinsonism and Related Disorders, vol.
Drugs Commonly Used for Treatment of Nausea and Vomiting Dopamine- Antihistamine Drugs Antagonist Drugs Anticholinergic Agents/ Dimenhydrinate Promethazine * Scopolamine (Dramamine[R]) (Phenergan[R]) (Transderm Scop[R]) Meclizine Prochlorperazine Trimethobenzamide
(Antivert[R]) (Compazine[R]) (Tigan[R]) Diphenhydramine Metoclopramide (Benadryl[R]) (Reglan[R]) Droperidol (Inapsine[R]) Chlorpromazine (Thorazine[R]) The FDA recently issued a "black box" warning for promethazine regarding the risks of IV push administration.
The antiemetics included ondansetron (six studies), domperidone (two studies), trimethobenzamide
(two studies), pyrilaminepentobarbital (two studies), metoclopramide (two studies), dexamethasone (one study), and promethazine (one study).
Tigan and other suppository drug products that contain trimethobenzamide
hydrochloride have not been shown to be effective for nausea and vomiting and should no longer be marketed, says the Food and Drug Administration.
Suppositories containing trimethobenzamide
, a sedating antihistamine, have been marketed under trade names that include Tigan, Tebamide, T-Gen, Trimazide, and Trimethobenz.
The FDA said patients can use alternative forms of the drug, trimethobenzamide
, marketed as capsules or injections by makers including King and Icelandic generic-drug maker Actavis Group hf.
She tried dexamethasone and trimethobenzamide
, and that helped to some degree.
Other common oral medications for NVP include prochlorperazine (Compazine), metoclopramide (Reglan), trimethobenzamide
(Tigan), promethazine (Phenergan), and ondansetron (Zofran).
HCI Amide Pharmaceutical Tigan capsules