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An example is CYP2E1 function, in which in vitro liver bank studies (Figure 4A, B) generally agree with in vivo drug metabolism data for the CYP2E1 substrate trimethadione (Figure 5) (Nakamura et al.
1/2] of busulfan (y) Biliary excretion Serum protein Adult level (aa) Serum cholinesterase Serum arylesterase Alcohol 91 % - in vitro EA (ee) dehydrogenase Abbreviations: APAP, acetaminophen; BSP, bromosulfophthalein; CBZ, carbamazepine; CBZ-E, carbamazepine-epoxide; DMO, dimethadione; EA, enzyme activity; EH, epoxide hydrolase; GFR, glomerular filtration rate; PL, protein level; TMO, trimethadione.
Trimethadione is the only dione available in the United States; paramethadione is used overseas and in Canada for absence seizures.