trimethadione


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trimethadione

 [tri″meth-ah-di´ōn]
an anticonvulsant with analgesic properties, administered orally for treatment of petit mal epilepsy.

trimethadione

/tri·meth·a·di·one/ (tri″meth-ah-di´ōn) an anticonvulsant with analgesic properties, used for the control of petit mal seizures.

trimethadione

(trī-mĕth′ə-dī′ōn′)
n.
A white crystalline substance, C6H9NO3, used as an anticonvulsant in the treatment of epilepsy.

trimethadione

[trī′methədī′ōn]
an anticonvulsant.
indications It is prescribed to prevent absence (petit mal) seizures, particularly seizures that are resistant to other therapies.
contraindications Severe renal or hepatic impairment, blood dyscrasias, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are exfoliative dermatitis, blood dyscrasias, and aplastic anemia. Sedation, diplopia, photophobia and hemeralopia (an inability to see as distinctly in bright light as in dim light) may occur.

trimethadione

Tridione® Pharmacology An oxazolidinedione  used for absence seizures Adverse effects Sedation, blurring of vision, exfoliative dermatitis, rashes, hepatitis, nephrosis, death

trimethadione (trīmeth´ədī´ōn),

n brand name: Tridione;
drug class: anticonvulsant;
action: increases the threshold for seizures initiated in the cortex, decreases central nervous system (CNS) synaptic stimulation to low-frequency impulses;
use: treatment of refractory absence (petit mal) seizures.
References in periodicals archive ?
An example is CYP2E1 function, in which in vitro liver bank studies (Figure 4A, B) generally agree with in vivo drug metabolism data for the CYP2E1 substrate trimethadione (Figure 5) (Nakamura et al.
1/2] of busulfan (y) Biliary excretion Serum protein Adult level (aa) Serum cholinesterase Serum arylesterase Alcohol 91 % - in vitro EA (ee) dehydrogenase Abbreviations: APAP, acetaminophen; BSP, bromosulfophthalein; CBZ, carbamazepine; CBZ-E, carbamazepine-epoxide; DMO, dimethadione; EA, enzyme activity; EH, epoxide hydrolase; GFR, glomerular filtration rate; PL, protein level; TMO, trimethadione.
Trimethadione is the only dione available in the United States; paramethadione is used overseas and in Canada for absence seizures.