trifluridine


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trifluridine

 [tri-floor´ĭ-dēn]
an antiviral compound that interferes with viral DNA synthesis, used topically in the treatment of keratitis and keratoconjunctivitis caused by human herpesviruses 1 and 2.
References in periodicals archive ?
trifluridine (FTD) and tipiracil (TPI), whose dual mechanism of action is designed to maintain clinical activity and differs from conventional fluoropyrimidines.
Lonsurf consists of a thymidine-based nucleoside analog, trifluridine, and the thymidine phosphorylase inhibitor, tipiracil, which increases trifluridine exposure by inhibiting its metabolism by TP.
Contract awarded for Purchase (delivery) of a medicinal product (drug) trifluridine with typiracil
According to the company, LONSURF consists of a thymidine-based nucleoside analog, trifluridine, and the thymidine phosphorylase (TP) inhibitor, tipiracil, which increases trifluridine exposure by inhibiting its metabolism by TP.
(8) A 2015 systematic review found that topical antivirals acyclovir, ganciclovir, brivudine, trifluridine were equally effective in treatment outcome; 90% of patients healed within 2 weeks.
Comparative antiviral efficacies of cidofovir, trifluridine, and acyclovir in the hsv-1 rabbit keratitis model.
The most common chemotherapy used for colon and rectal carcinoma treatment include 5-fluorouracil (5-FU, combined with folinic acid), capecitabine, irinotecan, oxaliplatin, and trifluridine (combined with tipiracil); however, resistance development and severe side effects are limitations commonly associated with the use of these drugs [2].
Taylor, "Therapeutic response of herpes simplex virus-induced corneal edema to trifluridine in combination with immunosuppressive agents," Invest Ophthalmol Vis Sci, vol.
Among antiviral drugs, trifluridine is category C and acyclovir is category B.
Topical trifluridine, iododeoxyuridine or vidarabine are used for treatment (2,50,59).
Greenstone has also introduced trifluridine ophthalmic solution, 1% sterile, the generic version of Viroptic.
After examination, the ophthalmologist stated this was not a bacterial infection but a viral infection, and prescribed trifluridine, an antiviral drug for topical treatment of epithelial keratitis caused by herpes simplex virus.