trifluridine


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trifluridine

 [tri-floor´ĭ-dēn]
an antiviral compound that interferes with viral DNA synthesis, used topically in the treatment of keratitis and keratoconjunctivitis caused by human herpesviruses 1 and 2.

trifluridine

/tri·flur·i·dine/ (-floor´ĭ-dēn) an antiviral compound that interferes with viral DNA synthesis, used topically in the treatment of keratitis and keratoconjunctivitis caused by human herpesviruses 1 and 2.

trifluridine (ophthalmic) (trī´floor´-idēn´ ofthal´mik),

n brand name: Viroptic ophthalmic solution;
drug class: antiviral;
action: inhibits viral deoxyribonucleic acid (DNA) synthesis and replication;
uses: treatment of primary keratoconjunctivitis, recurring epithelial keratitis, and keratitis associated with herpes simplex virus types 1 and 2.

trifluridine

an antiviral agent used topically in the treatment of herpesvirus infections of the eye.
References in periodicals archive ?
Lonsurf is a combination of trifluridine, a nucleoside metabolic inhibitor, and tipiracil, a thymidine phosphorylase inhibitor, indicated in US for the treatment of patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy.
Food and Drug Administration today approved Lonsurf (a pill that combines two drugs, trifluridine and tipiracil) for patients with an advanced form of colorectal cancer who are no longer responding to other therapies.
Among antiviral drugs, trifluridine is category C and acyclovir is category B.
Topical trifluridine, iododeoxyuridine or vidarabine are used for treatment (2,50,59).
Greenstone has also introduced trifluridine ophthalmic solution, 1% sterile, the generic version of Viroptic.
When herpesvirus is suspected, start the patient on an antiviral agent such as trifluridine ophthalmic (1%) 9 times a day, vidarabine ophthalmic (3%) 5 times daily, or 400 mg oral acyclovir 5 times a day.
After examination, the ophthalmologist stated this was not a bacterial infection but a viral infection, and prescribed trifluridine, an antiviral drug for topical treatment of epithelial keratitis caused by herpes simplex virus.
He received slit-lamp examination by a local ophthalmologist, who after consultation with CDC and NYSDOH, treated him with trifluridine ophthalmic solution (4).
Treatment with topical trifluridine in OS and systemic famciclovir was started.
The patient improved within 24 hours after treatment with trifluridine eyedrops and a single dose of intravenous vaccinia immune globulin.
In studies of mice infected with the virus, topical application of the drug proved as effective as trifluridine, the currently approved topical drug for human ocular herpesvirus infection.
Trifluridine (Viroptic) also has no eye human data.