A group used to protect amino moieties of amino acid and peptides during peptide synthesis.
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(S)-(-)-N(trifluoroacetyl)pyrrolidine-2-carbonyl chloride (L-TPC) is one of the well-known CDAs that is readily available in chemical market and shows impressive results in chiral separation of the phenylalkylamines mainly on GCMS after derivatization reaction [8, 9, 24].
Ethyl acetate, acetic acid, methanol, 2-propanol, ammonium hydroxide, dichloromethane, 0.1 M solution of (S)-(-)-N-(trifluoroacetyl)pyrrolidine-2-carbonyl chloride (L-TPC) with an enantiomer excess (ee) of 97% (according to the supplier's specification) in methylene chloride, anhydrous sodium sulfate, and sodium phosphate were obtained from Sigma-Aldrich Chemicals (St.
Asiri, "Synthesis and biological evaluation of new N,N'-Bis(1-substituted-ethylidene)-ethane1,2-diamine and their acetyl and trifluoroacetyl derivatives as cytotoxic and antimicrobial agents," Journal of Chemistry, vol.
Biochemical studies on the plant methanolic, hexane and aqueous extracts show the presence of the quinoline alkaloid lunacridine to be effective against tropical ulcers [16], antitubercular [14] and antibacterial activity [17,18], graveolinine, 4-methoxy-2-phenylquinoline and kokusagine for antituberculosis activity [19], lunacridine and its trifluoroacetyl derivative for DNA intercalation, topoisomerase II decatenation, cytotoxicity and caspase activation activities [16] and Cytochrome P450 2D6 inhibitory effect [20].
trifluoroacetic acid is formed in the trifluoroacetyl derivatization
To enhance the anxiolytic activity of some azepine derivatives by the introduction of a trifluoromethyl group in the dia-, oxa- or thiazepine, trifluoroacetyl ketene acetals 167 were reacted with o-aminothiophenol derivatives in the presence of xylene, applying a multimode microwave oven (8-12 min at 980 W).
(2006) Highly efficient synthesis of heterocyclic compounds based on reactivity of trifluoroacetyl group.
The 100 [micro]m polydimethylsiloxane provided the highest analytical sensitivity for the trifluoroacetyl derivative of 9-hydroxyphenanthrene, while the 70 [micro]m Carbowax[TM]/divinylbenzene provided the next best analytical sensitivity and a simpler chromatogram with less derivatization byproducts.
Time course of 72-kilodalton heat shock protein induction and appearance of trifluoroacetyl adducts in livers of halothane exposed rats.
[21] report the vibrational assignment of trifluoroacetyl acetone using B3LYP, B3PW91, BLYP, BPW91, and G96LYP functionals.
Residues were reconstituted and derivatized with 50 [micro]L of MBTFA at 70 [degrees]C for 45 min to obtain trifluoroacetyl derivatives of the analytes (30).