A group used to protect amino moieties of amino acid and peptides during peptide synthesis.
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Biochemical studies on the plant methanolic, hexane and aqueous extracts show the presence of the quinoline alkaloid lunacridine to be effective against tropical ulcers [16], antitubercular [14] and antibacterial activity [17,18], graveolinine, 4-methoxy-2-phenylquinoline and kokusagine for antituberculosis activity [19], lunacridine and its trifluoroacetyl derivative for DNA intercalation, topoisomerase II decatenation, cytotoxicity and caspase activation activities [16] and Cytochrome P450 2D6 inhibitory effect [20].
trifluoroacetic acid is formed in the trifluoroacetyl derivatization
by trifluoroacetyl, pentafluoropropionyl, or heptafluorobutyryl.
The so-called CF3 chemistry has been an important pillar for the site since the 1980s, when the production process for trifluoroacetyl chloride (TFAC) was developed.
They explained this result as follows: in this reaction the reactivity of the enehydrazine part was promoted by the enhancement of the LUMO character by the strong electro-attractivity of the trifluoroacetyl group, because in the [3,3]sigmatropy reaction exemplified by Claisen rearrangement, the reaction between two double bonds is well-known to proceed by an appropriate combination of HOMO and LUMO.
2006) Highly efficient synthesis of heterocyclic compounds based on reactivity of trifluoroacetyl group.
The 100 [micro]m polydimethylsiloxane provided the highest analytical sensitivity for the trifluoroacetyl derivative of 9-hydroxyphenanthrene, while the 70 [micro]m Carbowax[TM]/divinylbenzene provided the next best analytical sensitivity and a simpler chromatogram with less derivatization byproducts.
Another reagent, trifluoroacetic anhydride, was used to form a trifluoroacetyl derivative that gave a prominent and unique molecular ion in GC-MS for the analysis of hydroxy PAHs white improving their analytical sensitivity.
The DMDCS and TFAA derivatives, yielded more volatile derivatives compared to the 9-hydroxyphenanthrene parent compound due to the presence of the chlorine and trifluoroacetyl groups, respectively.
Due to the high electron affinity of fluorine substituents in the trifluoroacetyl derivative, the analytical sensitivity would be expected to be impressive when GC with electron-capture detection or mass spectrometry with chemical ionization in negative ion mode is used for the detection of the fluorinated derivative.
Time course of 72-kilodalton heat shock protein induction and appearance of trifluoroacetyl adducts in livers of halothane exposed rats.
Residues were reconstituted and derivatized with 50 [micro]L of MBTFA at 70 [degrees]C for 45 min to obtain trifluoroacetyl derivatives of the analytes (30).