Antipsychotic medication Drug substance Atypical Amisulpride Aripiprazole Clozapine Olanzapine Paliperidone Quetiapine Risperidone Sertindole Zotepine Typical Perphenazine Benperidol Chlorpromazine Chlorprothixene Droperidol Flupentixol Fluphenazine Haloperidol Levomepromazine Loxapine Oxypertine Pericyazine Pimozide Promazine Remoxipride Sulpiride Thioridazine Trifluoperazine
Trifluperidol Zuclopenthixol GPRD were recorded and collected independently from each other.
The drugs whose utilization accounted for about 90% of the entire drug use (DU 90%) include haloperidol, amitriptyline, benzhexol, trifluoperazine
, chlorpromazine, and carbamazepine.
(94) Also, another study (95) suggests that an existing phenothiazine-like antipsychotic drug, trifluoperazine
, has the ability to down-regulate cancer stem cell markers CD44 and CD133 and as such might possess anti-lung cancer stem cell properties.
Antipsychotic Medications, Generic and Brand Names and Typical Tablet Dosage Generic Name Brand Name Tablet dosage range Atypical Risperidone Risperdal 1-3 mg Olanzapine Zyprexa 2.5-10 mg Clozapine Clozaril 25-100 mg Quetiapine Seroquel 25-200 mg Ziprasidone Geodon 20-60 mg Aripiprazole Abilify 5-15 mg High Potency Haloperidol Haldol 0.5-20 mg Typical Pimozide Orap 2 mg Fluphenazine Prolixin 2.5-10 mg Medium Potency Trifluoperazine
Stelazine 1-10 mg Typical Perphenazine Trilafon 2-16 mg Thiothixene Navane 2-20 mg Loxapine Loxitane 5-50 mg Low Potency Molindone Moban 5-100 mg Typical Mesoridazine Serentil 10-100 mg Thioridazine Mellaril 10-200 mg Chlorpromazine Thorazine 10-200 mg Adapted from Wilens (1999) and Li, Pearrow, & Jimerson (2010).
Iliakis, "Modulation of adriamycin and N-trifluoroacetyladriamycin-14-valerate induced effects on cell cycle traverse and cytotoxicity in P388 mouse leukemia cells by caffeine and the calmodulin inhibitor trifluoperazine
," Cancer Research, vol.
Effects of A23187, nicardipine and trifluoperazine
," Atherosclerosis, vol.
Researchers from Case Western Reserve University School of Medicine and Mount Sinai School of Medicine found that the anti-psychotic medication trifluoperazine
can reactivate a gene pathway involved in tumor suppression that's normally turned off in lung cancer patients.
For inhibition of L-Type Calcium channel, NMDA receptor and CaM kinase, cells were preincubated with, adding 1.8 mM ketamine and 1[micro]M MK801, 15 min (treatment 1), 100 [micro]M nifedipine and 100 [micro]M flavoxate hydrochloride, 30 min (treatment 2) and 10 [micro]M trifluoperazine
, 30 min (treatment 3).
Besides matrix acidosis, the immunosuppressant cyclosporin A (16), its non-immunosuppressive analogues, N-methyl-valine cyclosporin and N-methylisoleucine cyclosporin (17), sanglifehrin A (18), bongkrekic acid (19), trifluoperazine
(20), magnesium, certain ubiquinone analogues (21) as well as volatile anaesthetic agents (22) and propofol (23) have all been shown to either block the open state or prevent assembly of the mPTP, thus preventing both necrotic and apoptotic cell death.
(37-39) Although case fatality rates in BAE are high ([greater than or equal to] 90%), some successful drug treatment combinations in balamuthiasis have included azoles (albendazole, fluconazole, or itraconazole), flucytosine, pentamidine, sulfadiazine; and synergistic anti-protozoal therapy with macrolide antibiotics (azithromycin or clarithromycin), phenothiazines (thioridazine or trifluoperazine
), and the experimental anti-Leishmania agent used to treat visceral leishmaniasis, miltefosine.
The other most commonly prescribed drugs were (in order) risperidone, haloperidol, olanzapine, chlorpromazine, trifluoperazine
, and quetiapine.
Drug Milligram equivalent to 20 Confidence mg of olanzapine (Zyprexa) Second generation antipsychotics Aripirazole (Abilify) 30 M Clozapine (Clozaril) 400 H Paliperidone (Invega) 9 M Quetiapine (Seroquel) 740 H Risperidone (Risperdal) 6 H First generation antipsychotics Haloperidol (Haldol) 10 H Perphenazine (Trilafon) 30 M Trifluoperazine
(Stelazine) 20 M Key: H = high confidence level; M = moderate confidence level.