, an antipsychotic agent, inhibits cancer stem cell growth and overcomes drug resistance of lung cancer.
Through experiments in human cells, human lung cancer tissue and mouse lung tissue, the team found that trifluoperazine
was able to stop the product of a gene called FOXO1 from being taken out of a tumor cell's nucleus.
Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine
In the study, the category of conventional antipsychotics included perphenazine, fluphenazine, trifluoperazine
, thiothixene, haloperidol, molindone, loxapine, prochlorperazine, acetophenazine, promazine, triflupromazine, thioridazine, mesoridazine and chlorprothixene.
Prolonged seizures and post-ECT seizures have been reported in patients who were concurrently taking desipramine and trifluoperazine
(Rey & Walter, 1997).
These drags include the major tranquilizers trifluoperazine
(Stelazine) and haloperidol (Haldol); metoclopramide (Reglan), used to treat gastroesophageal reflux and the nausea caused by certain cancer drugs; and less often, alpha methyldopa and reserpine, used to control hypertension.
She also became worse when treated with the antipsychotic trifluoperazine
, and later improved remarkably with 150 mg amitriptyline.
Haloperidol, chlorpromazine, trifluoperazine
, pimozide, and fluphenazine all were categorized as "intermediate" in carcinogenic potential based on available preclinical data.
Both subjects on trifluoperazine
and all 4 subjects on fluphenazine depot had no risk of suicide at the time of evaluation.
Most (93%) were taking either risperidone or haloperidol; other agents included thioridazine, chlorpromazine, and trifluoperazine