trientine

trientine

triethylenetetramine dihydrochloride; a copper-chelating agent used in the treatment of chronic hepatopathies in which copper accumulates.
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She was then provided physiotherapy and the alternative drug, Trientine which helps remove copper accumulation from the body, said Dr Nagral.
The therapeutic measures for this disorder revolve around chelating the excess copper using chelating agents such as tetrathiomolybdate, trientine and penicillamine.
Therapeutic approaches to Cu toxicity include the drugs and formulations such as D-penicillamine or trientine to prevent neurodegenerative disorder (78).
Wilson's Disease is treated with lifelong use of D-penicillamine or trientine hydrochloride, drugs that help remove copper from tissue, or zinc acetate, which stops the intestines from absorbing copper and promotes copper excretion.
Trientine, developed by New Zealand biotechnology company, Protemix, as Laszarin(TM) extracts oxidised copper, which is then excreted in the patient's urine.
Kenneth Reid, Professor of Immunochemistry, the University of Oxford, added: "Last year Professor Cooper's team announced that trientine appears to reverse heart disease in people suffering from diabetes and may lead to a more effective intervention in a major cause of death worldwide.
In an 8-week double-blind trial, 54 patients were randomized to 20 mg of tetrathiomolybdate (TM) six times a day (three times with meals, three times between meals) or to 500 mg of trientine twice a day
Neurologic status deteriorated in 1 of 27 patients on TM and 5 of 27 patients on trientine.
Trientine (Syprine) functions in a similar way and is gentler, but it has not been tested on patients with neurologic symptoms.
It looks like trientine will have a risk of neurologic deterioration less than penicillamine but higher than TM.
Until recently, the two chelation-therapy drugs of choice were trientine and penicillamine.