trientine

trientine

triethylenetetramine dihydrochloride; a copper-chelating agent used in the treatment of chronic hepatopathies in which copper accumulates.
References in periodicals archive ?
Trientine hydrochloride is used in the treatment of penicillamine-intolerant patients with Wilson's disease, a genetic disease that prevents the body from removing excess copper and potentially causing life-threatening organ damage.
The use of trientine in preventing the effects of interrupting penicillamine therapy in Wilson's disease.
Other drugs tested as copper chelators include trientine and D-penicillamine (Brem et al.
She was then provided physiotherapy and the alternative drug, Trientine which helps remove copper accumulation from the body, said Dr Nagral.
Western medicines for WD patients are d-penicillamine, sodium dimercaptosuccinate, dimercaptosuccinic acid, trientine, zinc preparation, tetrathiomolybdate, etc.
Medical therapy includes reducing dietary copper intake, antagonizing its absorption with zinc, or chelation with penicillamine or trientine.
The therapeutic measures for this disorder revolve around chelating the excess copper using chelating agents such as tetrathiomolybdate, trientine and penicillamine.
Therapy involves lifelong administration of either D- penicillamine or trientine hydrochloride; both of these drugs remove copper deposits by binding to the copper which is removed from the body via the urine.
Wilson's Disease is treated with lifelong use of D-penicillamine or trientine hydrochloride, drugs that help remove copper from tissue, or zinc acetate, which stops the intestines from absorbing copper and promotes copper excretion.
In an 8-week double-blind trial, 54 patients were randomized to 20 mg of tetrathiomolybdate (TM) six times a day (three times with meals, three times between meals) or to 500 mg of trientine twice a day