tricyclic antidepressant


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tri·cyc·lic an·ti·de·pres·sant

a chemical group of antidepressant drugs that share a three-ringed nucleus.

tricyclic antidepressant

n. Abbr. TCA
Any of a group of antidepressant drugs, such as amitryptyline, that contain three fused benzene rings and that block the reuptake of the neurotransmitters norepinephrine and serotonin in the central nervous system.

tricyclic antidepressant

Pharmacology Any psychoactive dibenzozepine derivative–eg, which have 3 central rings and a short linear chain attached to the terminal nitrogen and are thus tertiary amines Lab TA levels correlate poorly with the clinical status, as circulating levels of the highly lipid-soluble TCA represent a minute portion of the body load, and TCA metabolites with similar clinical effects may not be measured Clinical, overdose Parasympathetic disease with anticholinergic effects–eg, mydriasis, xerostomia, urinary retention, ↓ peristalsis, cardiac disease–intractable myocardial depression, hypotension, ventricular tachycardia, fibrillation, or heart block and CNS disease–confusion, agitation, hallucinations, myoclonus, seizures, lethargy that may progress to coma and respiratory arrest Adverse effects Dry mouth, constipation, blurred vision, hyperthermia, weakness, fatigue, lethargy, insomnia, confusion, seizures, ↓ peristalsis, hypotension, coma. See Desipramine, Imipramine, Nortriptyline, Therapeutic drug monitoring, Tricyclic antidepressant suicide. Cf Fluoxetine, Monoamine oxidase inhibitors.

tri·cyc·lic an·ti·de·pres·sant

(TCA) (trī-sīklik antē-dĕ-presănt)
Chemical group of antidepressant drugs that share a three-ringed nucleus.

tri·cyc·lic an·ti·de·pres·sant

(TCA) (trī-sīklik antē-dĕ-presănt)
Chemical group of antidepressants that share three-ringed nucleus.
References in periodicals archive ?
Wilkes, "Plasma alkalinization for tricyclic antidepressant toxicity: a systematic review," Emergency Medicine, vol.
Variability of recommendations for serum alkalinization in tricyclic antidepressant overdose: a survey of US poison center medical directors.
However, it is surprising that 297 respondents (73%) with cataplexy reporting mild to severe ADL interference, were not on tricyclic antidepressant medication (114 respondents reported mild interference, 107 reported moderate interference and 76 reported severe interference in this nontricyclic antidepressant medicated group).
Hansen et al (3) found that the adrenergic and anticholinergic effects of chronic treatment with tricyclic antidepressants do not result in a higher perioperative incidence of tachycardia, arrhythmia or hypertension.
The big difference between the treatment arms involved rates of unequivocal fitness to drive, which ranged from a high of around 50% in patients on mirtazapine, quetiapine, and reboxetine to 10% in those receiving a tricyclic antidepressant.
In 1993 we published a study that did not find an excess of birth defects in the babies of women who took the SSRI fluoxetine (Prozac) or tricyclic antidepressants during pregnancy.
Follow-up studies of children who were exposed to SSRIs or tricyclic antidepressants in utero show that their IQs, language development, and behavior do not differ from those of other children at up to 7 years of age.
DALLAS -- Tricyclic antidepressant overdoses are making a comeback in parallel with the medications' increasing use for indications other than depression.
A patient with depression, for example, may benefit from a tricyclic antidepressant, whereas a patient with hypertension may benefit from a [beta]-blocker.
and Oregon Health and Science University, Portland, identified all patients in a large health-claims database who were diagnosed with diabetic peripheral neuropathy, were aged 65 years or older, and had received a prescription for a tricyclic antidepressant (TCA).
While no more effective than traditional tricyclic antidepressant drugs, the new agents are generally safer than traditional medications used to treat depression: they are well tolerated and, in case of overdose, less harmful than tricyclic antidepressants.
This analysis of the National Ambulatory Medical Care Survey differs from previous analyses in that it documents a significant number of tricyclic antidepressant prescriptions by primary care physicians for nonpsychiatric disorders that are responsive to TCAs.