tricyclic antidepressant


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tri·cyc·lic an·ti·de·pres·sant

a chemical group of antidepressant drugs that share a three-ringed nucleus.

tricyclic antidepressant

n. Abbr. TCA
Any of a group of antidepressant drugs, such as amitryptyline, that contain three fused benzene rings and that block the reuptake of the neurotransmitters norepinephrine and serotonin in the central nervous system.

tricyclic antidepressant (TCA)

any of a group of antidepressant drugs that contain three fused rings in their chemical structure and that potentiate the action of catecholamines. These drugs rapidly block the reuptake of amine neurotransmitters, but the exact mechanism of their effect is unknown because a period of time is required for the beneficial antidepressant effects to appear. The tricyclic antidepressants include a number of compounds, which may be grouped into four classes on the basis of chemical structure: dibenzazepines, dibenzocycloheptadienes, dibenzoxazepines, and dibenzoxepines. Besides their use to treat depression, various tricyclic antidepressants are used for other conditions, such as obsessive-compulsive disorder, panic disorder, and neurogenic pain.

tricyclic antidepressant

Pharmacology Any psychoactive dibenzozepine derivative–eg, which have 3 central rings and a short linear chain attached to the terminal nitrogen and are thus tertiary amines Lab TA levels correlate poorly with the clinical status, as circulating levels of the highly lipid-soluble TCA represent a minute portion of the body load, and TCA metabolites with similar clinical effects may not be measured Clinical, overdose Parasympathetic disease with anticholinergic effects–eg, mydriasis, xerostomia, urinary retention, ↓ peristalsis, cardiac disease–intractable myocardial depression, hypotension, ventricular tachycardia, fibrillation, or heart block and CNS disease–confusion, agitation, hallucinations, myoclonus, seizures, lethargy that may progress to coma and respiratory arrest Adverse effects Dry mouth, constipation, blurred vision, hyperthermia, weakness, fatigue, lethargy, insomnia, confusion, seizures, ↓ peristalsis, hypotension, coma. See Desipramine, Imipramine, Nortriptyline, Therapeutic drug monitoring, Tricyclic antidepressant suicide. Cf Fluoxetine, Monoamine oxidase inhibitors.

tri·cyc·lic an·ti·de·pres·sant

(TCA) (trī-sīklik antē-dĕ-presănt)
Chemical group of antidepressant drugs that share a three-ringed nucleus.

tri·cyc·lic an·ti·de·pres·sant

(TCA) (trī-sīklik antē-dĕ-presănt)
Chemical group of antidepressants that share three-ringed nucleus.
References in periodicals archive ?
Value of the QRS duration versus the serum drug level in predicting seizures and ventricular arrhythmias after an acute overdose of tricyclic antidepressants.
Predicting severity of tricyclic antidepressant overdose.
However, it is surprising that 297 respondents (73%) with cataplexy reporting mild to severe ADL interference, were not on tricyclic antidepressant medication (114 respondents reported mild interference, 107 reported moderate interference and 76 reported severe interference in this nontricyclic antidepressant medicated group).
Hansen et al (3) found that the adrenergic and anticholinergic effects of chronic treatment with tricyclic antidepressants do not result in a higher perioperative incidence of tachycardia, arrhythmia or hypertension.
28) In addition to duloxetine and pregabalin, first-line agents include tricyclic antidepressants, SNRIs, calcium channel [alpha.
Tricyclic antidepressants, citalopram, and duloxetine were effective in small trials, as was treatment with opioids.
In 1993 we published a study that did not find an excess of birth defects in the babies of women who took the SSRI fluoxetine (Prozac) or tricyclic antidepressants during pregnancy.
In the pre-SSRI era, when tricyclic antidepressants (TCAs) ruled antidepressant therapy, TCA overdoses were among the most common and feared of all overdoses, with a lethality of 15%.
While no more effective than traditional tricyclic antidepressant drugs, the new agents are generally safer than traditional medications used to treat depression: they are well tolerated and, in case of overdose, less harmful than tricyclic antidepressants.
Charney DS, Heninger G R, Sternberg DE, Landis H: Abrupt discontinuation of tricyclic antidepressant drugs: Evidence for noradrenergic hyperactivity.
A few years ago, a meta-analysis of 30-year-old tricyclic antidepressant data concluded that [T.
If neither methylphenidate nor an amphetamine is effective, the next class of drugs to try is a tricyclic antidepressant, such as desipramine or imipramine.