tricyclic


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tricyclic

 [tri-sik´lik]
containing three fused rings or closed chains in the molecular structure; see also antidepressant.

tricyclic

(trī-sĭk′lĭk, -sī′klĭk)
adj.
Having or being a molecular structure that contains three closed rings: a tricyclic molecule.
n.
A tricyclic antidepressant drug.
References in periodicals archive ?
The big difference between the treatment arms involved rates of unequivocal fitness to drive, which ranged from a high of around 50% in patients on mirtazapine, quetiapine, and reboxetine to 10% in those receiving a tricyclic antidepressant.
Children treated with tricyclic drugs compared with those treated with placebo had approximately 1 less night of enuresis per week (WMD=1.19; 95% CI, -1.56 to -0.82).8 More children achieved 14 dry nights while on imipramine compared with placebo (21% vs 5%; NNT=6); however, this advantage was not sustained once treatment finished (96% vs 97% relapsed).
The tricyclics amitriptyline and desipramine, while effective, are less well tolerated, according to the guidelines.
Compared with placebo, tricyclic antidepressants have an aggregate NNT of 3.5 (95% confidence interval [CI], 2.6-4.7) for patients reporting at least 50% reduction of pain, along with an NNH of 2.7 (95% CI, 2.1-3.9) for minor adverse effects (typically the muscarinic effects of dry mouth, constipation, and blurred vision) and 17 (95% CI, 10-43) for side effects severe enough to cause withdrawal from a trial.
In that paper, tricyclic antidepressants had a number needed to treat of 3.6, comparing favorably to 7.7 for pregabalin, 7.2 for gabapentin, and 6.4 for serotonin norepinephrine reuptake inhibitors, mainly including duloxetine, Dr.
Keywords: Tricyclic Heterocycles, Sequential Knoevenagel-Michael addition, [alpha]-glucosidase inhibition, Antioxidants, Antibacterial studies.
Flecainide toxicity is treated in the same manner as a tricyclic antidepressant overdose.
They tested rats with the tricyclic antidepressant nortriptyline and found that it indeed was able to decrease the amount of abnormal protein that can build up in the brain.
Annual spend - PS9,002,824 | Dosulepin - formerly known as dothiepin, it is a tricyclic antidepressant.
The results suggest that fluoxetine causes less bone resorption than other selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors, or tricyclic antidepressants and "may be a safer choice for a cohort already predis-posed to poorer brain health," the researchers concluded in a poster presented at the 18th Congress of the International Psychogeriatric Association.
All of these findings suggest tricyclic antidepressant cardiotoxicity.
It found that while the substance appeared to have a more benign side effect and tolerance profile than a tricyclic alternative such as amitriptyline, it was less effective at treating the condition.