Physiological models were added for TCA and trichloroethanol
(TCOH), and a 2-compartment model was added for DCA.
trichloroethane oxidised to trichloroethanol
trichloroacetaldehyde and trichloroacetic acid, dichloromethane (methylene chloride CH2Cl2) oxidized to carbon monoxide (CO)
A unanimous jury found Miss Humphreys, of Upper Holloway, north London, died of trichloroethanol
poisoning and returned a verdict of death by misadventure.
Chloral hydrate, which is metabolized to trichloroethanol
, produces little habituation and confusion.
Increased formic acid excretion and the development of kidney toxicity in rats following chronic dosing with trichloroethanol
, a major metabolite of trichloroethylene.
Toxicology tests found she died of trichloroethanol
The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol
in B6C3F1 mice.
2008), which is rapidly metabolized to trichloroacetic acid (TCA) by aldehyde dehydrogenase (ALDH) or to trichloroethanol
(TCE) by alcohol dehydrogenase (ADH).
2006) concludes that pending the evaluation of a number of additional structural hypotheses, such as enterohepatic recirculation, plasma binding, and flow--or diffusion-limited treatment of tissue distribution, rigorous application of PBPK modeling to risk assessment appears feasible at least for TCE and its major oxidative metabolites, trichloroacetic acid (TCA) and trichloroethanol
Recent TCE PBPK modeling efforts, coupled with methodologic advances in characterizing uncertainty and variability, suggest that rigorous application of PBPK modeling to TCE risk assessment appears feasible at least for TCE and its major oxidative metabolites trichloroacetic acid and trichloroethanol
Recent studies of trichloroethanol
exploring an alternative hypothesis for kidney tumorigenesis have failed to establish the formation of formate as a key event for TCE-induced kidney tumors.