trichlorfon


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metrifonate

 [met″rĭ-fo´nāt]
an organophosphorous compound having potent anticholinesterase activity; used topically against ectoparasites and internally as an anthelmintic, especially effective against Schistosoma haematobium.

tri·chlor·fon

(trī-klōr'fon),
An organophosphorus compound effective against immature and mature stages of Schistosoma haematobium, but ineffective against other species of Schistosoma in humans.
Synonym(s): metrifonate

metrifonate

An organophosphate that is an irreversible inhibitor of acetylcholinesterase. Metrifonate had some currency for treating Schistosoma haematobium schistosomiasis, but proved less effective than praziquantel and is thus no longer used for this indication. It was being developed for Alzheimer's dementia, but was withdrawn due to adverse effects (respiratory paralysis and defects in neuromuscular transmission).
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References in periodicals archive ?
zonata has developed resistance against trichlorfon, malathion, bifenthrin, l-cyhalothrin and spinosad, while they still remained susceptible to methomyl.
The Italian laboratory analyzed foods of plant origin for several additional organochlorine pesticides and also tested for several organophosphorus pesticides and three related products: phosalone, trichlorfon, and thiram.
Figure 2 shows the I[C.sub.50] (concentration for 50% inhibition) values of fenthion, fenthion sulfoxide, fenthione sulfone, fenitrothion, fensulfothion, EPN, trichlorfon, and malathion against the androgenic activity of DHT at a concentration of [10.sup.-10] M.
The correlation coefficients ranged between 0.69 (permethrin) and 0.85 (trichlorfon).
(c)Fewer than five cases used captan, coumaphos, 2,2-dichlorovinyl dimethyl phosphate IDDVP), permethrin (for animals), and trichlorfon. (d) Category boundaries set at the median cumulative lifetime days of use of each pesticide among applicators who used them (i.e., both cases and controls).
These active ingredients include permethrin, carbofuran, acephate, carbendazim, omethoate and trichlorfon among others, says the 34-page report titled 'Pesticides in Kenya: Why our health, environment and food security are at stake.'
Zhixiang, A flow-injection chemiluminescent biomimetic immunoassay method using a molecularly imprinted polymer as a biomimetic antibody for the determination of trichlorfon, Food.
Zhou, "Molecularly imprinted polymer as sorbent for solid-phase extraction coupling to gas chromatography for the simultaneous determination of trichlorfon and monocrotophos residues in vegetables," Food Analytical Methods, vol.
Xu, "A study on biomimetic immunoassay-capillary electrophoresis method based on molecularly imprinted polymer for determination of trace trichlorfon residue in vegetables," Food Chemistry, vol.
Among these, Deltamethrin, Ivermectin, Cypermethrin, Fipronil, Trichlorfon and Dichlorvos are commonly used.
A method was developed for trichlorfon residue as dichlorovos analysis by GC-uECD.