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an organophosphorous compound having potent anticholinesterase activity; used topically against ectoparasites and internally as an anthelmintic, especially effective against Schistosoma haematobium.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
An organophosphorus compound effective against immature and mature stages of Schistosoma haematobium, but ineffective against other species of Schistosoma in humans.
Farlex Partner Medical Dictionary © Farlex 2012
metrifonateAn organophosphate that is an irreversible inhibitor of acetylcholinesterase. Metrifonate had some currency for treating Schistosoma haematobium schistosomiasis, but proved less effective than praziquantel and is thus no longer used for this indication. It was being developed for Alzheimer's dementia, but was withdrawn due to adverse effects (respiratory paralysis and defects in neuromuscular transmission).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.