triazole antifungals

triazole antifungals

Drugs used to treat skin, oral, vaginal and internal fungal infections. Examples are fluconazole (Diflucan), itraconazole (Sporanox) and voticonazole (Vfend).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Triazole antifungals have greatly improved survival (1); however, triazole-resistant A.
Triazole antifungal medications are the primary treatment for invasive A.
One thing worth mentioning about the drugs tacrolimus (FK 506) and cyclosporine and the triazole antifungals is that a reduction in the dose of the immunosuppressive drugs is advised when either one of them is being concomitantly administered with a triazole (28).
Yet a new advance has been recently reported that will aid us in the rational design of novel triazole antifungals. It is the determination of the crystal structure of the CYP51 from the model yeast Saccharomyces cerevisiae in complex with its substrate lanosterol and with the triazole inhibitors fluconazole and itraconazole (16).
Aspergillus fumigatus is the most common species recovered from cases of IA (90% of IA cases involving the lungs).[sup][1],[2] Triazole antifungals, such as itraconazole, posaconazole, and voriconazole, are first-line drugs in prophylaxis and treatment of IA.[sup][3] However, during the past decades, a number of clinical failures of IA management due to triazole-resistant A.
Well-known drugs with such effects include several macrolide antibacterials and triazole antifungals and preemptive tacrolimus dose-reduction has been proposed when drugs are to be administered concomitantly [3,12].
Fluconazole and itraconazole are both triazole antifungals. They have been licensed for the short-term oral treatment of vulvovaginal candidiasis and have been proved to be safer than both amphotericin B and ketoconazole.
Begg, "A simple high-performance liquid chromatography method for simultaneous determination of three triazole antifungals in human plasma," Antimicrobial Agents and Chemotherapy, vol.
This could be explained by the synergy demonstrated in vitro between calcineurin inhibitors and triazole antifungals against some species of mucormycosis [18,19].
Fluconazole and itraconazole are both triazole antifungals. They have been licensed for the short-term oral treatment of vaginal candidiasis and have proved to be safer than both amphotericin B and ketoconazole.5 Both of them have good safety and efficacy data.
Sibley, 1999) is a key moiety of a large number of triazole antifungals,These triazoles belong to the class of a widely used orally active broad-spectrum antifungals.
(1) Triazole antifungal agents play an important role in the treatment of a wide range of fungal infections and can save lives when used in treatment of systemic invasive fungal infections in severely ill patients.