antifungal agents play an important role in the treatment of a wide range of fungal infections and can save lives when used in treatment of systemic invasive fungal infections in severely ill patients.
A new triazole
, voriconazole (UK-109,496), blocks sterol biosynthesis in Candida albicans and Candida krusei.
fungicide is expected to remain dominant throughout the forecast period with preventive and post infective usage
resistance found in non-culturable Aspergillus fumigatus from lungs of patients with chronic fungal disease.
Again, the most dramatic effects were caused by the triazole
Signals at [delta]9.80 and [delta]4.60 ppm assigned for triazole
NH and coumarin NH group also are displayed.
Heating induces crosslinking by 1,3 dipolar cycloaddition between an azide and an alkyne to give a 1,3 triazole
linkage, resulting in a very stable structure.
The syntheses of triazole
and thiazolidinone derivatives have been previously reported by many researchers, and they normally required additional additives and long reaction time.
; Complex; Stability constant .Introduction
In organic light-emitting diode (OLED) applications, highly electron-deficient groups such as oxadiazole and triazole
(Tz) units have been introduced into the polymer backbone or as the side group as electron transporting units to adjust the charge-injecting and transporting properties of the copolymers [9-11].
The important biological activities of triazole
derivatives impelled us to take up the synthesis of these new combinational heterocycles which are likely to have augmented diverse biological activity.