triazolam


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Related to triazolam: Halcion

triazolam

 [tri-a´zo-lam]
a benzodiazepine used as a sedative and hypnotic in treatment of insomnia; administered orally.

triazolam

Apo-Triazo (CA), Gen-Triazolam (CA), Halcion

Pharmacologic class: Benzodiazepine

Therapeutic class: Sedative-hypnotic

Controlled substance schedule IV

Pregnancy risk category X

Action

Inhibits gamma-aminobutyric acid, a neurotransmitter that activates receptors at limbic, thalamic, and hypothalamic levels of CNS

Availability

Tablets: 0.125 mg, 0.25 mg, 0.5 mg

Indications and dosages

Insomnia

Adults: 0.125 to 0.5 mg P.O. at bedtime p.r.n. After 7 to 10 days, decrease dosage gradually and then discontinue.

Dosage adjustment

• Elderly or debilitated patients

Off-label uses

• Presurgical hypnotic

Contraindications

• Hypersensitivity to drug or other benzodiazepines

• Concurrent use of itraconazole, ketoconazole, or nefazodone

• Pregnancy

Precautions

Use cautiously in:

• hepatic or renal dysfunction, sleep apnea, respiratory compromise, psychosis

• history of suicide attempt or drug abuse

• elderly or debilitated patients

• breastfeeding patients

• children younger than age 18 (safety and efficacy not established).

Administration

• Don't give with grapefruit juice.

Adverse reactions

CNS: dizziness, excessive sedation, hangover, headache, anterograde or traveler's amnesia, confusion, incoordination, lethargy, depression, paradoxical excitation, light-headedness, psychological disturbance, euphoria

GI: nausea, vomiting

Other: physical or psychological drug dependence, drug tolerance, withdrawal symptoms (tremor, abdominal and muscle cramps, vomiting, diaphoresis, dysphoria, perceptual disturbances, insomnia)

Interactions

Drug-drug. Antidepressants, antihistamines, chloral hydrate, opioid analgesics, other psychotropic drugs: additive CNS depression

Cimetidine, disulfiram, fluconazole, hormonal contraceptives, isoniazid, itraconazole, ketoconazole, nefazodone, rifampin, and other drugs that inhibit CYP450-3A4-mediated metabolism: decreased oxidative metabolism and increased action of triazolam

Digoxin: increased digoxin blood level, greater risk of toxicity

Macrolide anti-infectives (such as azithromycin, clarithromycin, erythromycin): increased triazolam bioavailability

Probenecid: rapid onset and prolonged effects of triazolam

Ranitidine: increased triazolam blood level

Theophylline: decreased sedative effect of triazolam

Drug-food. Grapefruit juice: increased triazolam blood level and effects

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: increased CNS depression

Smoking: increased triazolam clearance

Patient monitoring

• Monitor neurologic status. Watch for paradoxical or rebound drug effects.

• Observe for signs of drug hoarding and drug abuse.

Patient teaching

• Tell patient to take at bedtime with a liquid other than grapefruit juice.

• Explain that drug is meant only for short-term use (7 to 10 days).

• Tell patient rebound insomnia may occur for 1 to 2 nights after he discontinues drug.

• Instruct patient to avoid alcohol use and smoking.

• Caution patient to avoid driving and other hazardous activities while under drug's influence.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, foods, herbs, and behaviors mentioned above.

triazolam

/tri·a·zo·lam/ (tri-a´zo-lam) a benzodiazepine used as a sedative and hypnotic in the treatment of insomnia.

triazolam

(trī-ā′zə-lăm)
n.
A benzodiazepine drug, C17H12Cl2N4, used for short-term treatment of insomnia.

triazolam

[tri·az′əlam]
a benzodiazepine hypnotic agent. This drug was withdrawn from the market in the United Kingdom; it continues to be available in the United States. Its prototype is lorazepam.
indication It is prescribed in the short-term treatment of insomnia.
contraindications Known sensitivity to this drug or to other benzodiazepines or concurrent use of drugs that block CYP3A4 (e.g., ketoconazole) prohibits its use. It is not given to pregnant women, lactating mothers, or patients younger than 18 years.
adverse effects Among the most serious adverse effects are anterograde amnesia, paradoxical reactions, tachycardia, depression, confusion or memory impairment, and visual disturbances.

triazolam

Halcion® Pharmacology A sedative-hypnotic benzodiazepine analogue. Adverse effects Drowsiness, ↓ concentration See Benzodiazepine.

triazolam (trī´az´əlam),

n brand name: Halcion;
drug class: benzodiazepine, sedative-hypnotic, controlled substance schedule IV;
action: produces central nervous system (CNS) depression by interacting with a benzodiazepine receptor to facilitate the action of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA);
use: treatment of insomnia.
Trichinella spiralis
n a round worm found in raw or undercooked pork products. The worm resides in muscle tissue and is implicated in trichinosis food poisoning. Symptoms of infection, when they occur, are similar to those of food poisoning.
References in periodicals archive ?
In contrast with these studies, however, Lindemann et al evaluated the effect of triazolam on the success rate of IANB in the patients with irreversible pulpitis and reported that the success rate of IANB in triazolam (a kind of benzodiazepine) group showed no statistically significant difference in comparison with the placebo group [31].
Co-administration of cisapride, dofetilide, ergot alkaloids such as dihydroergotamine, ergotamine, ergometrine (ergonovine), and methylergometrine (methylergonovine); felodipine, levacetylmethadol (levomethadyl), lovastatin, methadone, oral midazolam, nisoldipine, pimozide, quinidine, simvastatin, and triazolam with ONMEL[TM] is contraindicated.
Patients who are taking non-nucleoside reductase inhibitors should avoid alprazolam, midazolam, triazolam, and St.
Jurors were told Tobin had been treated in hospital after overdosing on triazolam in April 1990.
The Genpharm product line includes atenolol tablets, baclofen tablets, etidronate disodium tablets, sotalol tablets (AF), triazolam CIV, tizanidine HCl tablets, zonisamide capsules and meloxicam tablets.
The calibrators used were 1-hydroxymidazolam, 4-hydroxymidazolam, midazolam, 7-aminoclonazepam, desmethylflunitrazepam, flunitrazepam, and 7-aminoflunitrazepam (all from Lipomed); alprazolam, bromazepam, clonazepam, triazolam, lorazepam, 3-hydroxyflunitrazepam, zolpidem, and zopiclone (all from Sigma); flurazepam, desalkylflurazepam, [alpha]-hydroxyalprazolam, [alpha]-hydroxytriazolam, and the deuterated internal standards (IS) 7-aminoflunitrazepam-[d.
This issue has been recognised as a serious problem since the early 1990s following the high profile ban of the benzodiazepine Triazolam in 1993.
The earlier sleep medication was triazolam, sold as Halcion.
25-milligram-strength triazolam pill, better known as Halcyon and commonly used as a prescription sleeping aid.
Commonly prescribed benzodiazepine sleep-aids are: flurazepam (Dalmane), estazolam (ProSom), temazepam (Restoril) and triazolam (Halcion).
The following drugs have been found to interact with grapefruit juice (to be sure of your medications, ask your pharmacist): calcium channel blockers (for high blood pressure)--felodipine (Plendil), nifedipine (Procardia, Adalat), nisoldipine (Sular); immunosuppressant drugs (for organ transplants)--cyclosporine (Neoral, Sandimmune, SangCya), tacrolimus (Prograf); drugs for anxiety, insomnia or depression--diazepam (Valium), triazolam (Halcion), zaleplon (Sonata), carbamazepine (Tegretol), clomipramine (Anafranil).