"Fortunately, the youth was brought to the hospital within the three-hour stroke treatment window
," Dr Jamal Alkoteesh, consultant and chief of interventional radiologist at Al Ain Hospital, told Gulf News.
Expanded treatment window
in preclinical models to 72 hours post-infection versus Tamiflu (oseltamivir), which loses its ability to protect when administered beyond 24 hours post-infection
Key findings suggest CB-012 offers: Superior in vitro activity compared to standard-of-care antivirals and coverage of both influenza A and B viruses; Full protection from, or treatment of, H1N1, H3N2, and Tamiflu-resistant H1N1-related infections with a single dose of CB-012 in preclinical efficacy models; Long half-life in multiple preclinical species; Efficacy in multiple dosing formulations including intravenous, subcutaneous and intramuscular; Expanded treatment window
in preclinical models to 72 hours post-infection versus Tamiflu (oseltamivir), which loses its ability to protect when administered beyond 24 hours post-infection.
Following revised American Heart Association guidelines released earlier in 2018 that extended the treatment window
for stroke patients to 24 hours, Hackensack University Medical Center and Jersey Shore University Medical Center are poised to double the number of patients eligible for treatment and quadruple the window for treatment eligibility, according to data sighted by HMH.
The prior treatment window
for mechanical thrombectomy was up to six hours, however select patients with salvageable brain tissue identified through advanced imaging are now eligible for treatment up to twenty-four hours after they were last seen well.
This unique combination could position TMS-007 as a best in class thrombolytic for individuals with acute ischemic stroke with potential for an extended treatment window
as compared to current thrombolytic agents.
National guidelines published in 2009 extended the treatment window
from 3 to 4.5 hours in a further subgroup of patients.
Their goal is to reduce damage from stroke, while extending the treatment window
7 Patients who have an ischemic stroke, may have a treatment window
for mechanical clot removal within six hours to up to 24 hours in certain patients with clots in large vessels.
From their assessment, they said that artemisinin could significantly speed up the delivery of existing antibiotics, and in the case of TB, that shorter treatment window
could make all the difference.
Cleveland-based Athersys, with a market value of about $200 million, demonstrated evidence in a mid-stage trial that its therapy may be able to expand the emergency treatment window
for major strokes to up to 36 hours, compared with about four hours with current drugs, potentially allowing many more patients to avoid crippling disabilities.