In the largest study, conducted over the course of nine weeks with more than 1,100 adults with chronic insomnia and depression, the treatment arm
received the investigational PDT, and the comparator arm received an attention-matched digital placebo along with usual care.
In the DARZALEX-Rd treatment arm
, patients received DARZALEX 16 milligrams per kilogram (mg/kg) IV weekly.
Few patients, roughly 20% in each treatment arm
, had achieved the primary endpoint, a complete cure (0% nail involvement and negative KOH stain and culture) at the end of active treatment, Dr.
The baseline characteristics for participants in each treatment arm
were similar, except that participants in the vaginal estriol group were less symptomatic at baseline.
The incidence rate of treatment-related adverse events was 26.5% for the placebo arm, 53.4% for the 10 mg/kg monthly treatment arm
and 47.2% for the 10 mg/kg biweekly treatment arm
The study's primary endpoint was the percentage of patients in each treatment arm
who had a "successful" outcome, defined as at least a 50% improvement in their gastroesophageal reflux health-related quality of life score (J Gastrointest Surg.
Second, there was an important baseline difference between the treatment arms
in day of illness at study enrollment: Patients presenting later in their illness were more likely to be allocated to the hypertonic saline treatment arm
in 6 of the 18 studies assessed, most of which were small positive studies.
About half of the patients enrolled in the trial underwent microbiologic assessment of their infecting pathogen, and about 40% of cases in each treatment arm
had infections caused by S.
16 November 2011 - South Korean civil engineering group GS Engineering & Construction Corp (SEO:006360) on Wednesday announced the acquisition of Inima SAU, the environmental and water treatment arm
of Spanish builder Obrascon Huarte Lain SA (MCE:OHL), for EUR231m (USD311m).
A minimum of 35 patients per treatment arm
(70 in total) were required to have an 80% power of detecting a true difference in primary outcome with [alpha] of 0.05.
The study also found a statistically significant reduction in the risk of extrapulmonary tuberculosis in the early treatment arm
: 17 cases occurred in the deferred treatment arm
, compared with 3 cases in the early treatment arm