Table 1 Medications associated with serotonin syndrome Class Medication(s) Antidepressants Selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants Monoamine oxidase inhibitors Trazodone
Mirtazapine Triptans Almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan Anxiolytics Buspirone Antiemetics Ondansetron, granisetron, metoclopramide Herbal supplements St.
Procedures: During the first of 3 experiments, birds received orally administered trazodone
at doses ranging from 3 to 30 mg/kg to determine the dose for subsequent experiments.
Klein and her colleagues noted that 871 unique children were prescribed 5,190 30-day-supply prescriptions for trazodone
, including 23 children under age 5.
Regarding the persistence of priapism following discontinuation of the original inciting agent, trazodone
, it has been hypothesized that this may be due to irreversible fibrotic changes in penile smooth muscle which persist following the withdrawal of trazodone
Bupropion (Wellbutrin) and trazodone
are two other drugs that may be used.
Professor Giovanna Mallucci, who led the team from the Medical Research Council's Toxicology Unit in Leicester and Cambridge University, said: "We know that trazodone
is safe to use in humans, so a clinical trial is now possible to test whether the protective effects of the drug we see on brain cells in mice with neurodegeneration also apply to people in the early stages of Alzheimer's and other dementias.
Medications not recommended for treating either sleep initiation or sleep maintenance insomnia include: diphenhydramine, melatonin, tiagabine, trazodone
, tryptophan, and valerian.
In the absence of any emotional and behavioral problem, he has been diagnosed with primary insomnia, and he has been prescribed with trazodone
Patient and her familywere informed of the possible alternatives for managing the relapse of symptomatology including the further rising of paroxetine or mirtazapine dosage; augmentation strategies (including thyroid hormones and mood stabilizers or antipsychotics in lower doses); the addition of a third antidepressant that has sedative properties and relatively well tolerable side-effect profile, such as trazodone
; or alternatively ECT.
Targeting dopaminergic pathways to increase desire, an extended-release daily oral combination of trazodone
and bupropion, to be marketed as Lorexys, is about to begin phase III clinical trials.
It may also interact negatively with certain prescription medications and over-the-counter drugs, including: NSAIDs (such as aspirin and ibuprofen); warfarin (Coumadin); ticlopidine (Ticlid); clopidogrel (Plavix); and dipyridamole (Persantine) alprazolam (Xanax), haloperidol (Haldol), Trazodone
(Desyrel), omeprazole (Prilosec), and nifedipine (Procardia).
25-50mg works well for many PWD with fewer side effects than other medications.