OTX-TP (intracanalicular travoprost
insert) is an intracanalicular insert in Phase 3 clinical development for the reduction of intraocular pressure in patients with primary open-angle glaucoma and ocular hypertension.
The company's earlier stage assets include OTX-TIC, an extended-delivery intracameral travoprost
implant for the reduction of intraocular pressure in patients with glaucoma and ocular hypertension, as well as sustained release intravitreal implants for the treatment of retinal diseases.
Contract award notice: Conclusion of non-exclusive discount agreements pursuant to section 130a (8) sgb v on medicines containing the active substance timolol and travoprost
(atc: S01ed63) as part of a so-called open-house model (germany-eisenberg: Pharmaceutical products)
Ocular Therapeutix announced topline results from the first pivotal Phase 3 clinical trial of OTX-TP, an intracanalicular insert that delivers a preservative-free formulation of the drug travoprost
for the reduction of intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension.
Sustained effect of travoprost
on diurnal and nocturnal intraocular pressure.
As an example, both latanoprost and travoprost
are aimed at glaucoma treatment, but the tolerability of either drug among patients varies.
In this study, LayerBio's proprietary intracameral extended-release formulation of the glaucoma drug travoprost
is shown to lower intraocular pressure to therapeutic levels for longer than six months.
IOP of the OD remained consistently above 50 mmHg with medications provided (i.e., travoprost
, timolol, brinzolamide, brimonidine tartrate, and mannitol 20%).
The currently prescribed PGAs in our region are bimatoprost 0.01% (with BAK 0.02%), latanoprost 0.005% (with BAK 0.02%), travoprost
0.004% (with 0.001% polyquad), and tafluprost 0.0015% (preservative-free).
Later in 2014, Kucukevcilioglu and coworkers (2) described deepening of the upper eyelid sulcus in other PA, such as Latanoprost and Travoprost
. Other studies describe different side effects of PA, such as conjunctival hyperemia, elongation and darkening of eyelashes, induced iris darkening, and periocular skin pigmentation (3-5).
Prostaglandin analogues and mouse intraocular pressure: effects of tafluprost, latanoprost, travoprost
, and unoprostone, considering 24-hour variation.
and prostaglandin analogs such as latanoprost, travoprost
are playing an increasingly important role in the first-line therapy of glaucoma [6,8] The ocular hypotensive effect of once daily 0.5% timolol ranges from 17% to 28% which overlaps with that of twice daily timolol.